Juxtaglomerular cell tumour

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Juxtaglomerular cell tumour, abbreviated JCT, is a rare kidney tumour associated with hypertension and typically seen in adolescents or young adults.

It is also known as juxtaglomerular tumour and reninoma.[1]

General

  • Rare.
  • Etiology: increased renin.
  • Typically adolescents or young adults.[2]

Clinical:[1]

  • Hypertension.
  • Increased aldosterone.
    • Causes hypokalemia.
  • Increased plasma renin.

Microscopic

Features:[3]

  • Polygonal cells.
  • Abundant granular, eosinophilic cytoplasm.[4]
  • Perinuclear halo.

DDx:[2]

Images

Stains

Cytoplasmic granules.[4]

  • PAS +ve.
  • PASD +ve.

IHC

Features:

  • CD34 +ve.[2]
  • Vimentin +ve.
  • Actin +ve.
  • Cytokeratin -ve.[3]
  • HMB-45 -ve.[3]

Others:[2]

  • CD31 -ve.
  • Desmin -ve.
  • S-100 -ve.
  • Chromogranin -ve.
  • Synaptophysin -ve.
  • NSE -ve.

EM

Features:

  • Vesicles - contain renin.[5]

See also

References

  1. 1.0 1.1 Wong, L.; Hsu, TH.; Perlroth, MG.; Hofmann, LV.; Haynes, CM.; Katznelson, L. (Feb 2008). "Reninoma: case report and literature review.". J Hypertens 26 (2): 368-73. doi:10.1097/HJH.0b013e3282f283f3. PMID 18192852.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Kuroda, N.; Gotoda, H.; Ohe, C.; Mikami, S.; Inoue, K.; Nagashima, Y.; Petersson, F.; Alvarado-Cabrero, I. et al. (2011). "Review of juxtaglomerular cell tumor with focus on pathobiological aspect.". Diagn Pathol 6: 80. doi:10.1186/1746-1596-6-80. PMID 21871063.
  3. 3.0 3.1 3.2 3.3 Chao, CT.; Chang, FC.; Wu, VC.; Chen, JC. (Jan 2011). "Reninoma.". Kidney Int 79 (2): 260. doi:10.1038/ki.2010.445. PMID 21191395.
  4. 4.0 4.1 Hanna, W.; Tepperman, B.; Logan, AG.; Robinette, MA.; Colapinto, R.; Phillips, MJ. (Apr 1979). "Juxtaglomerular cell tumour (reninoma) with paroxysmal hypertension.". Can Med Assoc J 120 (8): 957-9. PMID PMC = 1819229 436071 PMC = 1819229.
  5. URL: http://path.upmc.edu/cases/case29/micro.html. Accessed on: 18 December 2011.