Difference between revisions of "Hibernoma"
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| Gross = lobulated lesion, light-brown, usually extremities | | Gross = lobulated lesion, light-brown, usually extremities | ||
| Grossing = | | Grossing = | ||
| Site = [[soft tissue lesions|soft tissue]] - [[adipocytic lesions]] | | Site = cervical-supraclavicular, periaortic - both thorax and the abdomen, perirenal; see ''[[soft tissue lesions|soft tissue]]'' - [[adipocytic lesions]] | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = young adults | | Clinicalhx = typically young adults | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
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| ClinDDx = [[Lipoma]] | | ClinDDx = [[Lipoma]] | ||
}} | }} | ||
'''Hibernoma''', also '''tumour of brown fat''',<ref>{{Cite journal | last1 = SHUTE | first1 = D. | title = Tumours of brown fat. | journal = Can Med Assoc J | volume = 71 | issue = 5 | pages = 484-5 | month = Nov | year = 1954 | doi = | PMID = 13209434 }}</ref> is an uncommon [[adipocytic tumour]]. | '''Hibernoma''', also '''tumour of [[brown fat]]''',<ref>{{Cite journal | last1 = SHUTE | first1 = D. | title = Tumours of brown fat. | journal = Can Med Assoc J | volume = 71 | issue = 5 | pages = 484-5 | month = Nov | year = 1954 | doi = | PMID = 13209434 }}</ref> is an uncommon [[adipocytic tumour]]. | ||
==General== | ==General== | ||
| Line 36: | Line 36: | ||
Epidemiology: | Epidemiology: | ||
*Young adults. | *Young adults - disappears with age.<ref name=pmid31281288>{{cite journal |authors=Zoico E, Rubele S, De Caro A, Nori N, Mazzali G, Fantin F, Rossi A, Zamboni M |title=Brown and Beige Adipose Tissue and Aging |journal=Front Endocrinol (Lausanne) |volume=10 |issue= |pages=368 |date=2019 |pmid=31281288 |pmc=6595248 |doi=10.3389/fendo.2019.00368 |url=}}</ref> | ||
==Gross== | ==Gross== | ||
*Well-circumscribed. | *Well-circumscribed. | ||
*Lobulated and light-brown on sectioning. | *Lobulated and light-brown on sectioning. | ||
Locations:<ref name=pmid31281288/> | |||
*Cervical-supraclavicular. | |||
*Periaortic - both thorax and the abdomen. | |||
*Perirenal. | |||
==Microscopic== | ==Microscopic== | ||
| Line 56: | Line 61: | ||
<gallery> | <gallery> | ||
Image:Hibernoma1.jpg | Hibernoma - high mag. (WC) | Image:Hibernoma1.jpg | Hibernoma - high mag. (WC) | ||
Image: | Image:Hibernoma2.jpg | Hibernoma - intermed mag. (WC) | ||
Image:Hibernoma3.jpg | Hibernoma - low mag. (WC) | Image:Hibernoma3.jpg | Hibernoma - low mag. (WC) | ||
</gallery> | </gallery> | ||
Latest revision as of 16:00, 22 April 2024
| Hibernoma | |
|---|---|
| Diagnosis in short | |
 Hibernoma. H&E stain. | |
|
| |
| LM | large polygonal/oval cells with central & small nucleus; nucleoli typically prominent; cytoplasm multivacuolated, oval, eosinophilic, granular |
| LM DDx | reaction to silicone implant |
| Gross | lobulated lesion, light-brown, usually extremities |
| Site | cervical-supraclavicular, periaortic - both thorax and the abdomen, perirenal; see soft tissue - adipocytic lesions |
|
| |
| Clinical history | typically young adults |
| Prevalence | uncommon |
| Prognosis | benign |
| Clin. DDx | Lipoma |
Hibernoma, also tumour of brown fat,[1] is an uncommon adipocytic tumour.
General
- Consists of brown fat (present in the infants to generate heat).[2]
- Benign.
- Usually asymptomatic.[3]
Epidemiology:
- Young adults - disappears with age.[4]
Gross
- Well-circumscribed.
- Lobulated and light-brown on sectioning.
Locations:[4]
- Cervical-supraclavicular.
- Periaortic - both thorax and the abdomen.
- Perirenal.
Microscopic
Features:[5]
- Large polygonal/oval cells:
- +/-Prominent blood vessels, central.[8]
DDx:
- Reaction to silicone implant.
Images
Hibernoma - high mag. (WC)
Hibernoma - intermed mag. (WC)
Hibernoma - low mag. (WC)
See also
References
- ↑ SHUTE, D. (Nov 1954). "Tumours of brown fat.". Can Med Assoc J 71 (5): 484-5. PMID 13209434.
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 605. ISBN 978-0781765275.
- ↑ Ahmed SA, Schuller I (December 2008). "Pediatric hibernoma: a case review". J. Pediatr. Hematol. Oncol. 30 (12): 900–1. doi:10.1097/MPH.0b013e318184e6dd. PMID 19131775.
- ↑ 4.0 4.1 Zoico E, Rubele S, De Caro A, Nori N, Mazzali G, Fantin F, Rossi A, Zamboni M (2019). "Brown and Beige Adipose Tissue and Aging". Front Endocrinol (Lausanne) 10: 368. doi:10.3389/fendo.2019.00368. PMC 6595248. PMID 31281288. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595248/.
- ↑ Chen DY, Wang CM, Chan HL (March 1998). "Hibernoma. Case report and literature review". Dermatol Surg 24 (3): 393–5. PMID 9537018.
- ↑ http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70271-6
- ↑ http://surgpathcriteria.stanford.edu/softfat/hibernoma/
- ↑ URL: http://radiographics.rsna.org/content/24/5/1433.full. Accessed on: 11 February 2013.