Difference between revisions of "Glycoprotein non-metastatic B"

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(Created page with "'''Glycoprotein non-metastatic B''', abbreviated '''GPNMB''', is an immunostain. It is typically positive in TSC1/TSC2/MTOR mutated renal cell carcinomas.<ref name=pmid37...")
 
 
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It is typically positive in TSC1/TSC2/MTOR mutated renal cell carcinomas.<ref name=pmid37661807>{{cite journal |authors=Li H, Argani P, Halper-Stromberg E, Lotan TL, Merino MJ, Reuter VE, Matoso A |title=Positive GPNMB Immunostaining Differentiates Renal Cell Carcinoma With Fibromyomatous Stroma Associated With TSC1/2/MTOR Alterations From Others |journal=Am J Surg Pathol |volume=47 |issue=11 |pages=1267–1273 |date=November 2023 |pmid=37661807 |doi=10.1097/PAS.0000000000002117 |url=}}</ref>
It is typically positive in TSC1/TSC2/MTOR mutated renal cell carcinomas.<ref name=pmid37661807>{{cite journal |authors=Li H, Argani P, Halper-Stromberg E, Lotan TL, Merino MJ, Reuter VE, Matoso A |title=Positive GPNMB Immunostaining Differentiates Renal Cell Carcinoma With Fibromyomatous Stroma Associated With TSC1/2/MTOR Alterations From Others |journal=Am J Surg Pathol |volume=47 |issue=11 |pages=1267–1273 |date=November 2023 |pmid=37661807 |doi=10.1097/PAS.0000000000002117 |url=}}</ref>


==Positive==
*[[Angiomyolipoma]].
*[[TFE3-rearranged renal cell carcinoma]].
*[[TFEB-rearranged renal cell carcinoma]].
*[[Low-grade oncocytic tumour]] (LOT).
*[[PEComa]].
*[[Renal cell carcinoma with fibromyomatous stroma]].
Others:
*[[Leiomyosarcoma]].{{fact}}
==Negative==
*[[Clear cell renal cell carcinoma]].
*[[Papillary renal cell carcinoma]].
*[[Chromophobe renal cell carcinoma]].
*[[Clear cell papillary renal cell tumour]].


==References==
==References==

Latest revision as of 13:33, 26 March 2024

Glycoprotein non-metastatic B, abbreviated GPNMB, is an immunostain.

It is typically positive in TSC1/TSC2/MTOR mutated renal cell carcinomas.[1]

Positive

Others:

Negative

References

  1. Li H, Argani P, Halper-Stromberg E, Lotan TL, Merino MJ, Reuter VE, Matoso A (November 2023). "Positive GPNMB Immunostaining Differentiates Renal Cell Carcinoma With Fibromyomatous Stroma Associated With TSC1/2/MTOR Alterations From Others". Am J Surg Pathol 47 (11): 1267–1273. doi:10.1097/PAS.0000000000002117. PMID 37661807.