Difference between revisions of "Classification of urothelial carcinoma by immunohistochemistry"
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===A simple classification of urothelial carcinoma=== | ===A simple classification of urothelial carcinoma=== | ||
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{{familytree | | | | | | | | | A01 | | | | |A01=[[Urothelial carcinoma]]}} | {{familytree | | | | | | | | | A01 | | | | |A01='''[[Urothelial carcinoma]]'''}} | ||
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{{familytree | | | | B01 | | | | | | | | B02|B01=Luminal type<br>GATA3 +ve | {{familytree | | | | B01 | | | | | | | | B02|B01='''Luminal type'''<br>'''GATA3 +ve'''<br>(CK5/6 -ve)|B02='''Basal type'''<br>'''CK5/6 +ve'''<br>(GATA3 -ve)}} | ||
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{{familytree | C01 | | | | C02 | | | | | | | | | | | |C01=Genomically unstable<br>p16 +ve|C02=Urothelial-like<br>p16 -ve}} | {{familytree | C01 | | | | C02 | | | | | | | | | | | |C01='''Genomically unstable'''<br>'''p16 +ve'''|C02='''Urothelial-like'''<br>'''p16 -ve'''}} | ||
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Revision as of 18:33, 15 October 2021
A classification of urothelial carcinoma by immunohistochemistry can be done with three immunostains.[1]
General
A simple classification of urothelial carcinoma
| Urothelial carcinoma | |||||||||||||||||||||||||||||||||||||||||
| Luminal type GATA3 +ve (CK5/6 -ve) | Basal type CK5/6 +ve (GATA3 -ve) | ||||||||||||||||||||||||||||||||||||||||
| Genomically unstable p16 +ve | Urothelial-like p16 -ve | ||||||||||||||||||||||||||||||||||||||||
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The immunoprofile (GATA3 POSITIVE, p16 POSITIVE, CK5/6 negative,) is in keeping with UROTHELIAL CARCINOMA, LUMINAL TYPE, GENOMICALLY UNSTABLE.
The immunoprofile (GATA3 POSITIVE, p16 negative, CK5/6 negative) is in keeping with UROTHELIAL CARCINOMA, LUMINAL TYPE, UROTHELIAL-LIKE.
The immunoprofile (CK5/6 POSITIVE, GATA3 negative) is in keeping with UROTHELIAL CARCINOMA, BASAL TYPE.
See also
References
- ↑ "Three-antibody classifier for muscle invasive urothelial carcinoma and its correlation with p53 expression". J Clin Pathol. June 2021. doi:10.1136/jclinpath-2021-207573. PMID 34103388.