Signet ring cell-like adenocarcinoma of the prostate
Signet ring cell-like adenocarcinoma of the prostate is a rare aggressive form of prostate cancer.
It is also known as signet ring cell carcinoma of the prostate and prostatic signet ring cell carcinoma.
The term "signet ring cell-like" is preferred over "signet ring cell" as per the WHO 5th Edition, as the cells are often mucin negative.[1]Cite error: Closing </ref> missing for <ref> tag
- Criteria vary - percentage of SRCs required for Dx varies from 20% to 50%.[2]
Microscopic
Features:
- Signet ring cells.
- Large cytoplasmic vacuole, peripherical nucleus with a crescent shape.[1]
- +/-Conventional prostatic carcinoma.
DDx:
- Acinar adenocarcinoma - Gleason pattern 4 with very small glands.
- Metastatic signet ring cell carcinoma.
Images
- Prostatic SRCC (nih.gov).
- Prostatic SRCC (nature.com).
- Prostatic SRCC (nature.com).
- Prostatic SRCC (webpathology.com) - looks like acinar adenocarcinoma.
Stains
- Alcian blue-PAS stain +ve.
- PAS - 50% of cases +ve.[2]
- Alcian blue - 44% of cases +ve.[2]
Note:
- May be mucin stain -ve.
IHC
- PSAP +ve.[2]
- PSA +ve.
- CEA -ve.
Note:
- If prostate stains (PSAP, PSA, NKX3.1) are negative, a GI primary should be excluded. Clinical correlation may be required.
See also
References
- ↑ 1.0 1.1 Sakalauskaite M, Garnelyte A, Civilka I, Dulskas A, Kincius M, Patasius A (May 2024). "Prostate Adenocarcinoma with Signet-Ring Cells and Features of Mucin: A Clinical Case and Literature Review". Medicina (Kaunas) 60 (6). doi:10.3390/medicina60060877. PMC 11205309. PMID 38929494. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11205309/.
- ↑ 2.0 2.1 2.2 2.3 Cite error: Invalid
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