Biphasic hyalinizing psammomatous renal cell carcinoma

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Biphasic hyalinizing psammomatous renal cell carcinoma, abbreviated BHP RCC, is a rare type of renal cell carcinoma with mutations in neurofibromin 2.^[1]

Microscopic

Features:

Biphasic cytomorphology:
1. Small cells.
2. Large cells.
Psammoma bodies.

DDx:

TFEB renal cell carcinoma.

References

↑ "Biphasic Hyalinizing Psammomatous Renal Cell Carcinoma (BHP RCC): A Distinctive Neoplasm Associated With Somatic NF2 Mutations". Am J Surg Pathol 44 (7): 901–916. July 2020. doi:10.1097/PAS.0000000000001467. PMC 7350624. PMID 32217839. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350624/.

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Diagnosis