Foregut primary carcinomas
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Foregut primary carcinomas can be difficult to definitively categorize on the basis of pathology alone, as their immunostaining patterns significantly overlap.[1]
Foregut primary directs to this article.
Foregut
The foregut includes the following:
- Esophagus.
- Stomach.
- Duodenum, proximal portion - to the ampulla of Vater.
- Liver.
- Gallbladder.
- Pancreas.[2]
- Lower respiratory tract.
IHC
Foregut carcinomas are typically:
- CK7 +ve.
- CK20 -ve.
- CDX2 -ve.
A (query) foregut primary panel for liver lesions:
- AE1/AE3, CK7, CK20, CK19, CDX2, HepPar-1, CA-125, GATA3, PAX8, WT-1, TTF-1.
See also
References
- ↑ Lee, MJ.; Lee, HS.; Kim, WH.; Choi, Y.; Yang, M. (May 2003). "Expression of mucins and cytokeratins in primary carcinomas of the digestive system.". Mod Pathol 16 (5): 403-10. doi:10.1097/01.MP.0000067683.84284.66. PMID 12748245.
- ↑ Jennings RE, Berry AA, Kirkwood-Wilson R, Roberts NA, Hearn T, Salisbury RJ, Blaylock J, Piper Hanley K, Hanley NA (October 2013). "Development of the human pancreas from foregut to endocrine commitment". Diabetes 62 (10): 3514–22. doi:10.2337/db12-1479. PMC 3781486. PMID 23630303. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781486/.