Microcystic elongated and fragmented glands in endometrioid endometrial carcinoma

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Microcystic elongated and fragmented glands in endometrioid endometrial carcinoma is a pattern of endometrioid endometrial carcinoma. Microcystic elongated and fragmented glands is typically abbreviated as MELF.[1]

General

  • MELF pattern is a poor prognosticator.[2]

Microscopic

Features:

  • Irregular elongated glands ("microcystic elongated fragmented") - at deep aspect of tumour.
    • Surrounded by stromal mucin.[3]
    • May be confused with LVI.

Notes:

  • Mucinous differentiation common in MELF.[3]
  • Lymphovascular invasion more commmon than non-MELF carcinomas.[2]

See also

References

  1. ↑ Euscher, E.; Fox, P.; Bassett, R.; Al-Ghawi, H.; Ali-Fehmi, R.; Barbuto, D.; Djordjevic, B.; Frauenhoffer, E. et al. (Nov 2013). "The pattern of myometrial invasion as a predictor of lymph node metastasis or extrauterine disease in low-grade endometrial carcinoma.". Am J Surg Pathol 37 (11): 1728-36. doi:10.1097/PAS.0b013e318299f2ab. PMID 24061515.
  2. ↑ 2.0 2.1 "Lymphovascular space invasion in microcystic elongated and fragmented (MELF)-pattern well-differentiated endometrioid adenocarcinoma is associated with a higher rate of lymph node metastasis". Int. J. Gynecol. Pathol. 33 (2): 127–34. March 2014. doi:10.1097/PGP.0b013e318285657b. PMID 24487466.
  3. ↑ 3.0 3.1 Stewart CJ, Brennan BA, Leung YC, Little L (2009). "MELF pattern invasion in endometrial carcinoma: association with low grade, myoinvasive endometrioid tumours, focal mucinous differentiation and vascular invasion". Pathology 41 (5): 454–9. doi:10.1080/00313020903041135. PMID 19900084.
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