E-cadherin
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E-cadherin is a common immunostain.
Mutations in the epithelial cadherin gene (E-cadherin), also known as CDH1, are associated with hereditary diffuse gastric cancer syndrome).[1][2]
Negative
- Lobular breast carcinoma.
- Atypical lobular hyperplasia.
- Lobular carcinoma in situ.
- Gastric adenocarcinoma, diffuse type.
Images
ALH with E-cadherin loss of staining - intermed. mag.
ALH with E-cadherin loss of staining - high mag.
Normal
Normal stain pattern:
- Complete membrane staining.
Comment:
- Partial loss is considered negative staining.
Images
Benign breast - intermed. mag.
Benign breast - high mag.
Benign breast - high mag.
