Atypical lobular hyperplasia
Jump to navigation
Jump to search
Atypical lobular hyperplasia, abbreviated ALH, a pre-malignant change in the breast characterized by cellular proliferation and cellular dyscohesion.
It can be seen as the precursor to lobular carcinoma in situ, the precursor of lobular carcinoma.
General
- May occur with ductal involvement by cells of atypical lobular hyperplasia (abbreviated DIALH).[1]
- ALH with DIALH has a risk of developing breast cancer that is similar to LCIS.
Microscopic
Features:
- Extent criterium: <50% of terminal duct lobular unit (TDLU) is involved.
- See lobular carcinoma in situ for details.
DDx:
Images
ALH - low mag. (WC)
ALH - intermed. mag. (WC)
ALH - high mag. (WC)
ALH - E-cadherin - intermed. mag. (WC)
ALH - E-cadherin - high mag. (WC)
Benign breast - E-cadherin - intermed. mag. (WC)
Benign breast - E-cadherin - high mag. (WC)
Benign breast - E-cadherin - high mag. (WC)
IHC
- E-cadherin -ve or incomplete membrane staining.