P40
| P40 | |
|---|---|
| Immunostain in short | |
| Similar stains | p63 |
| Use | lung (adenocarcinoma vs. squamous) |
| Normal staining pattern | nuclear staining |
| Positive | squamous cell carcinoma, urothelial carcinoma |
| Negative | prostate carcinoma, most lung adenocarcinoma, breast carcinoma |
p40 an immunostain that is both sensitive and specific for squamous cell carcinoma.
General
- Considered superior to p63 as it is more specific.[1]
- p63 stains a significant number of adenocarcinoma.
Staining
Positive
Negative
- Lung adenocarcinoma.
- Breast carcinoma.
- CK5 +ve breast carcinoma are typically p40 positive.[3]
See also
- p63.
References
- ↑ Bishop, JA.; Teruya-Feldstein, J.; Westra, WH.; Pelosi, G.; Travis, WD.; Rekhtman, N. (Mar 2012). "p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma.". Mod Pathol 25 (3): 405-15. doi:10.1038/modpathol.2011.173. PMID 22056955.
- ↑ Brandler, TC.; Aziz, MS.; Rosen, LM.; Bhuiya, TA.; Yaskiv, O. (Jun 2014). "Usefulness of GATA3 and p40 immunostains in the diagnosis of metastatic urothelial carcinoma in cytology specimens.". Cancer Cytopathol 122 (6): 468-73. doi:10.1002/cncy.21424. PMID 24711443.
- ↑ Kővári, B.; Szász, AM.; Kulka, J.; Marušić, Z.; Šarčević, B.; Tiszlavicz, L.; Cserni, G. (Sep 2015). "Evaluation of p40 as a Myoepithelial Marker in Different Breast Lesions.". Pathobiology 82 (3-4): 166-71. doi:10.1159/000375127. PMID 26330357.