Tumour-infiltrating lymphocytes
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Tumour-infiltrating lymphocytes. H&E stain.
Tumour-infiltrating lymphocytes, abbreviated TILs, is the presence of many lymphoctyes between tumour cells.
TILs in the context of colorectal carcinoma are dealt with in intratumoural lymphocytic response in colorectal carcinoma.
General
Common finding in a large number of tumours:
| Tumour | Association |
|---|---|
| Colorectal carcinoma | microsatellite instability[1] |
| Malignant melanoma | |
| Non-small cell lung cancer | assoc. with anti-PD-L1 response[2] |
| Ovarian serous carcinoma | good prognosis[3] |
See also
References
- ↑ Iacopetta, B.; Grieu, F.; Amanuel, B. (Dec 2010). "Microsatellite instability in colorectal cancer.". Asia Pac J Clin Oncol 6 (4): 260-9. doi:10.1111/j.1743-7563.2010.01335.x. PMID 21114775.
- ↑ Fehrenbacher, L.; Spira, A.; Ballinger, M.; Kowanetz, M.; Vansteenkiste, J.; Mazieres, J.; Park, K.; Smith, D. et al. (Mar 2016). "Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial.". Lancet. doi:10.1016/S0140-6736(16)00587-0. PMID 26970723.
- ↑ Webb, JR.; Milne, K.; Kroeger, DR.; Nelson, BH. (May 2016). "PD-L1 expression is associated with tumor-infiltrating T cells and favorable prognosis in high-grade serous ovarian cancer.". Gynecol Oncol 141 (2): 293-302. doi:10.1016/j.ygyno.2016.03.008. PMID 26972336.