Gastric ulcer
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Gastric ulcer, also stomach ulcer, is pathology of the stomach that is evident grossly. It can be benign or malignant.
General
- May be benign or malignant.
Causes:
Gross
- Heaped (raised) edges - suggestive of cancer.
- Punched-out appearance with flat edges - suggestive of benign.
Notes:
- The edges of the ulcer are classically biopsied, as the dictum is: the cancer is there; this dictum may not be true.[1]
Images
Malignant ulcer of the stomach. (WC)
Microscopic
Features:
- Loss of the (gastric) epithelium.
- Vital reaction.
- Marked (acute) inflammation.
- Fibrin.
Images
SU - low mag. (WC)
SU - intermed. mag. (WC)
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Compatible with benign
A. STOMACH, BIOPSY: - GASTRIC ANTRAL-TYPE MUCOSA WITH EDEMA, FOCALLY PROMINENT SMOOTH MUSCLE, ACTIVATED FIBROBLASTS, A MILD INCREASE OF EOSINOPHILS, AND FIBRIN -- COMPATIBLE WITH NEARBY ULCER. - NEGATIVE FOR HELICOBACTOR-LIKE ORGANISMS. - NEGATIVE FOR INTESTINAL METAPLASIA. - NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.
See also
- ↑ Lv, SX.; Gan, JH.; Ma, XG.; Wang, CC.; Chen, HM.; Luo, EP.; Huang, XP.; Wu, SH. et al. (May 2012). "Biopsy from the base and edge of gastric ulcer healing or complete healing may lead to detection of gastric cancer earlier: an 8 years endoscopic follow-up study.". Hepatogastroenterology 59 (115): 947-50. doi:10.5754/hge10692. PMID 22469743.