Osteochondroma
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Osteochondroma is a common benign chondro-osseous tumour.[1]
General
- Benign.
- Very common.
- Abnormal outgrowth of bone and cartilage - associated with growth plate.
- Usually present before age 20.[2]
Gross
Features:
- Metasphyseal lesions.[3]
- Mushroom-like shape - with broad or narrow base.
Note:
- Very unusual in craniofacial bones.[2]
Microscopic
Features:[2]
- Bone - forms base of "mushroom".
- Cartilage - layer usu. thinner in older individuals.
- Lobular arrangement[5] - clusters of 3-12 lacunae (separated by stroma).
- May have mild atypia.
- Nuclear enlargement - up to 5x normal.
- Perichondrium - covers the cartilage.
- Thin layer of cells - higher cellular density than cartilage.
- Bland spindle cells in a fibrous (eosinophilic) stroma.
- Thin layer of cells - higher cellular density than cartilage.
Notes:
- Benign cartilage - one chondrocyte per lacuna, small and round nucleus, no binucleation.
DDx:
- Chondrosarcoma - esp. in older individuals.
Images
Bone - Osteochondroma - low power (SKB)
Bone - Osteochondroma - low power (SKB)
Bone - Osteochondroma - high power (SKB)
Bone - Osteochondroma - low power (SKB)
Bone - Osteochondroma - medium power (SKB)
Bone - Osteochondroma - medium power (SKB)
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See also
References
- ↑ Rogozhin, DV.; Bulycheva, IV.; Kushlinsky, NE.; Konovalov, DM.; Talalaev, AG.; Roshchin, VY.; Ektova, AP.; Kushnir, BL. et al. "[Osteochondroma in children and adolescents].". Arkh Patol 77 (3): 37-40. PMID 26226780.
- ↑ 2.0 2.1 2.2 2.3 Parkin, B.; Bennett, JC.; Zaher, A. (Aug 2003). "Pathologic quiz case: an iliac mass in a 25-year-old woman. Osteochondroma.". Arch Pathol Lab Med 127 (8): e355-6. doi:10.1043/1543-2165(2003)127e355:PQCAIM2.0.CO;2. PMID 12873205.
- ↑ URL: http://www.medpath.info/MainContent/Skeletal/Bone_07.html. Accessed on: 18 September 2012.
- ↑ Kokavec, M.; Gajdoš, M.; Džupa, V. (2011). "[Osteochondroma of the iliac crest: case report].". Acta Chir Orthop Traumatol Cech 78 (6): 583-5. PMID 22217414.
- ↑ 5.0 5.1 URL: http://path.upmc.edu/cases/case341/dx.html. Accessed on: 19 September 2012.