Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia

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Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, abbreviated DIPNECH, is an uncommon lung pathology that is considered pre-neoplastic by the WHO.[1]

General

  • Rare.
  • Usually women (15 of 19 cases[2]).
  • Typically non-smokers (16 of 19 cases[2]).

Clinical:[3]

  • Typical patient in 60s.
  • Cough.

Treatment:

  • Somatostatin analogs[3] - improves cough.

Gross

  • Multiple small pulmonary nodules.[1]

DDx:

Microscopic

See typical lung carcinoid tumour

See also

References

  1. ↑ 1.0 1.1 Wirtschafter, E.; Walts, AE.; Liu, ST.; Marchevsky, AM. (Jun 2015). "Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Lung (DIPNECH): Current Best Evidence.". Lung. doi:10.1007/s00408-015-9755-1. PMID 26104490.
  2. ↑ 2.0 2.1 Davies, SJ.; Gosney, JR.; Hansell, DM.; Wells, AU.; du Bois, RM.; Burke, MM.; Sheppard, MN.; Nicholson, AG. (Mar 2007). "Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease.". Thorax 62 (3): 248-52. doi:10.1136/thx.2006.063065. PMID 17099078.
  3. ↑ 3.0 3.1 Chauhan, A.; Ramirez, RA. (Jun 2015). "Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) and the Role of Somatostatin analogs: A Case Series.". Lung. doi:10.1007/s00408-015-9754-2. PMID 26112453.
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