CDX2
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CDX2 immunostains in a case of papillary thyroid carcinoma cribriform morular variant. (WC)
CDX2 is a commonly used immunostain in pathology. It is a nuclear stain.
Normal
- Intestinal epithelium.[1]
Pathology
- Intestinal adenocarcinomas +ve.
- Colorectal adenocarcinoma.
- Small bowel adenocarcinoma +ve/-ve (~43% +ve in series of 189 cases[2]).
- Ovarian mucinous adenocarcinoma +ve.[1]
- Lung adenocarcinoma -ve (<5% +ve in 20 cases[3]).
- Yolk sac tumour (8 of 20 cases - versus glypican-3).[4]
References
- ↑ 1.0 1.1 Groisman, GM.; Meir, A.; Sabo, E. (Jan 2004). "The value of Cdx2 immunostaining in differentiating primary ovarian carcinomas from colonic carcinomas metastatic to the ovaries.". Int J Gynecol Pathol 23 (1): 52-7. doi:10.1097/01.pgp.0000101141.31270.a0. PMID 14668551.
- ↑ Jun, SY.; Eom, DW.; Park, H.; Bae, YK.; Jang, KT.; Yu, E.; Hong, SM. (Mar 2014). "Prognostic significance of CDX2 and mucin expression in small intestinal adenocarcinoma.". Mod Pathol. doi:10.1038/modpathol.2014.36. PMID 24603585.
- ↑ Tanaka, S.; Saito, K.; Ito, T.; Tajima, K.; Mogi, A.; Shitara, Y.; Sano, T.; Kuwano, H. (Jul 2007). "CDX2 as a useful marker of colorectal adenocarcinoma metastases to lung in pre-operative biopsy specimens.". Oncol Rep 18 (1): 87-92. PMID 17549351.
- ↑ Bing, Z.; Pasha, T.; Tomaszewski, JE.; Zhang, P. (Oct 2009). "CDX2 expression in yolk sac component of testicular germ cell tumors.". Int J Surg Pathol 17 (5): 373-7. doi:10.1177/1066896909338598. PMID 19578052.