Pilomyxoid astrocytoma
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Pilomyxoid astrocytoma is a neuropathology tumour related to pilocytic astrocytoma.
General
Features:[1]
- A variant of pilocytic astrocytoma.
- Some have suggested it is a unique entity.[2]
- Childhood or adolescence.
Grading:
- WHO Grade II by definition.[1]
Gross
Features:[1]
- Classically - hypothalamic location/suprasellar location; may involve the sella turcica.[3]
- Solid.
- Well-circumscribed.
Microscopic
Features:[1]
- Consists of small round/ovoid bland cells in a myxoid stroma.
- Hair-like fibres ~ 1 micrometer.
- Often difficult to appreciate on standard (H&E) histologic sections.
- Usually angiocentric (surround blood vessel) - key feature.
Notes:[1]
- Rosenthal fibres are absent - key negative.
- Monophasic (unlike classical pilocytic astrocytomas) - key negative.
- May rarely have eosinophilic granular bodies.
Images
Pilomyxoid astrocytoma. (WC/Marvin 101)
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Perry, Arie; Brat, Daniel J. (2010). Practical Surgical Neuropathology: A Diagnostic Approach: A Volume in the Pattern Recognition series (1st ed.). Churchill Livingstone. pp. 86. ISBN 978-0443069826.
- ↑ Komotar RJ, Mocco J, Jones JE, et al. (June 2005). "Pilomyxoid astrocytoma: diagnosis, prognosis, and management". Neurosurg Focus 18 (6A): E7. PMID 16048293.
- ↑ Alimohamadi M, Bidabadi MS, Ayan Z, Ketabchi E, Amirjamshidi A (December 2009). "Pilomyxoid astrocytoma with involvement of the sella turcica in an adolescent". J Clin Neurosci 16 (12): 1648–9. doi:10.1016/j.jocn.2009.01.035. PMID 19766001.