Squamous cell carcinoma of the penis

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Squamous cell carcinoma of the penis
Diagnosis in short

Squamous carcinoma of the penis. H&E stain.
LM DDx squamous dysplasia, pseudoepitheliomatous hyperplasia
Gross mass lesion, scaly patches/nodules, usu. erythematous, +/-ulceration.
Grossing notes penectomy
Site penis
Clinical history uncircumcised
Prevalence uncommon overall, most common form of penis cancer
Prognosis good
Treatment surgery

Squamous cell carcinoma of the penis is the most common malignancy of the penis.

Penile cancer redirects to this article.

General

  • Not very common overall.[1]
  • Most common form of penile cancer.
    • Non-squamous penis cancer only ~5% of cases.[2]

Epidemiology:[1]

  • Median age ~ 67 years old.
  • Usually a good outcome - 5 year cause specific survival ~ 81%.[1]

Gross

  • Scaly patches/nodules.
  • Usually erythematous.
  • +/-Ulceration.

Microscopic

Features:

Notes:

DDx:

Grading

  • G1 - well differentiated. §
    • Almost normal appearing - diagnosis of malignancy may be challenging.
  • G2 - moderately differentiated. §
  • G3 - poorly differentiated.
    • Anaplastic cells.
    • Typically little or no keratinization.
  • GX - cannot be assessed.

Notes:

Staging

T-stage:

  • pT1a - subepithelial tissue involved, no LVI, not poorly differentiated (G3 or G4).
  • pT1b - subepithelial tissue involved with LVI or poorly differentiated.
  • pT2 - corpus spongiosum or cavernosum involved.
  • pT3 - urethral involvement.
  • pT4 - adjacent structure(s) involved.

Images

  • Penile SCC - low mag.

  • Penile SCC - high mag.

  • Penile SCC - high mag.

  • Penile SCC - intermed. mag.

  • Penile SCC - high mag.

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TIP OF PENIS, PARTIAL PENECTOMY:
- INVASIVE SQUAMOUS CELL CARCINOMA, MODERATELY DIFFERENTIATED.
-- SURGICAL MARGINS NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.
-- PLEASE SEE TUMOUR SUMMARY.

TIP OF PENIS, PARTIAL PENECTOMY:
- INVASIVE SQUAMOUS CELL CARCINOMA OF CORONAL SULCUS, MODERATELY DIFFERENTIATED.
-- SURGICAL MARGINS NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.
- LICHEN SCLEROSIS.
- POST-SURGICAL CHANGES (GRANULOMATOUS INFLAMMATION (NON-NECROTIZING), SIDEROPHAGES).

COMMENT:
This lesion was previously excised. The surgical clearance is 1 mm. The tumour 
thickness is approximately 4 mm. No lymphovascular invasion is identified. No 
lymphovascular invasion is identified. No corpus spongiosum or corpus cavernosum
invasion is seen. The staging is unchanged.

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 Burt, LM.; Shrieve, DC.; Tward, JD. (Jan 2014). "Stage presentation, care patterns, and treatment outcomes for squamous cell carcinoma of the penis.". Int J Radiat Oncol Biol Phys 88 (1): 94-100. doi:10.1016/j.ijrobp.2013.08.013. PMID 24119832.
  2. ↑ Moses, KA.; Sfakianos, JP.; Winer, A.; Bernstein, M.; Russo, P.; Dalbagni, G. (Dec 2013). "Non-squamous cell carcinoma of the penis: single-center, 15-year experience.". World J Urol. doi:10.1007/s00345-013-1216-y. PMID 24292119.
  3. ↑ Bhagat, SK.; Gopalakrishnan, G.; Kekre, NS.; Chacko, NK.; Kumar, S.; Manipadam, MT.; Samuel, P. (Feb 2010). "Factors predicting inguinal node metastasis in squamous cell cancer of penis.". World J Urol 28 (1): 93-8. doi:10.1007/s00345-009-0421-1. PMID 19488760.
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