Succinate dehydrogenase
Succinate dehydrogenase, abbreviated SDH, is an enzyme complex in the citric acid cycle and electron transport chain. It is localized to the mitochondria.
Immunostain
- It is used to look for mitochondrial disease.
- Loss of staining is pathologic.
Associated pathology
Mutations in SDH genes are associated with:
- Paraganglioma.[1]
- Pheochromocytoma.[1]
- Succinate dehydrogenase renal cell carcinoma.[2]
- Gastrointestinal stromal tumour.
- SDHA mutations = good outcome.[3]
See also
References
- ↑ 1.0 1.1 Vicha, A.; Taieb, D.; Pacak, K. (Jun 2014). "Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma.". Endocr Relat Cancer 21 (3): R261-77. doi:10.1530/ERC-13-0398. PMID 24500761.
- ↑ Ricketts, CJ.; Shuch, B.; Vocke, CD.; Metwalli, AR.; Bratslavsky, G.; Middelton, L.; Yang, Y.; Wei, MH. et al. (Dec 2012). "Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer.". J Urol 188 (6): 2063-71. doi:10.1016/j.juro.2012.08.030. PMID 23083876.
- ↑ Pantaleo, MA.; Lolli, C.; Nannini, M.; Astolfi, A.; Indio, V.; Saponara, M.; Urbini, M.; La Rovere, S. et al. (Sep 2014). "Good survival outcome of metastatic SDH-deficient gastrointestinal stromal tumors harboring SDHA mutations.". Genet Med. doi:10.1038/gim.2014.115. PMID 25188872.