Renal cell carcinoma with rhabdoid morphology
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Renal cell carcinoma with rhabdoid morphology is an uncommon finding with a poor prognosis. It is also known as renal cell carcinoma with rhabdoid change.
General
- Not recognized as a distinct entity.[1]
Microscopic
Features:
- Rhabdoid cells:
- Eccentrically placed large round nuclei with very prominent nucleoli.
- Abundant eosinophilic cytoplasm.
Notes:
- May be multinucleated.
IHC
Features:[2]
- Vimentin +ve (23 of 23 cases).
- NSE +ve (~80% of cases).
- S-100 -ve/+ve (+ve ~ 40% of cases).
- Desmin -ve (23 of 23 cases).
- SMA -ve (~5% of cases).
See also
References
- ↑ Chapman-Fredricks, JR.; Herrera, L.; Bracho, J.; Gomez-Fernandez, C.; Leveillee, R.; Rey, L.; Jorda, M. (Oct 2011). "Adult renal cell carcinoma with rhabdoid morphology represents a neoplastic dedifferentiation analogous to sarcomatoid carcinoma.". Ann Diagn Pathol 15 (5): 333-7. doi:10.1016/j.anndiagpath.2011.03.002. PMID 21665507.
- ↑ Gökden, N.; Nappi, O.; Swanson, PE.; Pfeifer, JD.; Vollmer, RT.; Wick, MR.; Humphrey, PA. (Oct 2000). "Renal cell carcinoma with rhabdoid features.". Am J Surg Pathol 24 (10): 1329-38. PMID 11023094.