Atypical adenomatous hyperplasia of the lung
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Atypical alveolar hyperplasia of the lung is considered the precursor of lung adenocarcinoma. It is typically found beside lung adenocarcinoma in resection specimens.[1]
General
- Generally considered the precursor lesion to adenocarcinoma in situ.[2]
- Typically an incidental finding, i.e. asymptomatic.[3]
Microscopic
Features:[3]
- Enlarged alveolar lining cells with:
- Hobnail morphology - free (luminal) surface area > attached/basal surface area.
- Hyperchromasia.
- Spaces are typically seen between the cells.[4]
- Limited extent:
- <5 mm. †
DDx:
- Adenocarcinoma in situ.
- Lung adenocarcinoma.
Note:
Images
See also
References
- ↑ Travis, WD.; Brambilla, E.; Noguchi, M.; Nicholson, AG.; Geisinger, KR.; Yatabe, Y.; Beer, DG.; Powell, CA. et al. (Feb 2011). "International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.". J Thorac Oncol 6 (2): 244-85. doi:10.1097/JTO.0b013e318206a221. PMID 21252716.
- ↑ 2.0 2.1 Sakuma, Y.; Matsukuma, S.; Yoshihara, M.; Nakamura, Y.; Nakayama, H.; Kameda, Y.; Tsuchiya, E.; Miyagi, Y. (Sep 2007). "Epidermal growth factor receptor gene mutations in atypical adenomatous hyperplasias of the lung.". Mod Pathol 20 (9): 967-73. doi:10.1038/modpathol.3800929. PMID 17618248.
- ↑ 3.0 3.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 114. ISBN 978-0781765275.
- ↑ Travis, WD.; Brambilla, E.; Noguchi, M.; Nicholson, AG.; Geisinger, KR.; Yatabe, Y.; Beer, DG.; Powell, CA. et al. (Feb 2011). "International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.". J Thorac Oncol 6 (2): 244-85. doi:10.1097/JTO.0b013e318206a221. PMID 21252716.