Colorectal xanthomatous polyp

The colorectal xanthomatous polyp, also colorectal xanthoma, is a rare benign intestinal polyp.

General

• Rare.
• May be associated with hyperlipidemia (7/25 patients in one series).

Gross

• Yellow or cream colour.

Microscopic

Features:

• Abundant foamy histiocytes in the superficial lamina propria.
• +/-Superficial serrations (hyperplastic features).
  • Seen in ~80% of cases.

DDx:

• Hyperplastic polyp.
• Signet ring cell carcinoma.

IHC

• CD68 +ve (foamy histiocytes).

Sign out

POLYP, SIGMOID COLON, POLYPECTOMY:
- XANTHOMATOUS POLYP WITH HYPERPLASTIC FEATURES.
- NEGATIVE FOR DYSPLASIA.

COMMENT:
Xanthomatous polyps may be seen in the context of hyperlipidemia.

See also

• Intestinal polyps.
• Gastric xanthoma.