Bile duct adenoma
Bile duct adenoma is a benign liver lesion characterized composed of bile duct epithelium.
It is also known as a benign bile duct proliferation.[1]
General
- Benign.
- Important as it can be misdiagnosed as cancer.
Microscopic
Features:
- Disordered bile ducts within in a fibrotic stroma.
- No (yellow) bile within, as these lesions do not have a connection to the biliary tree.
- +/-Lymphocytic cuff.[2]
Negatives:
- No mitotic activity.
- No necrosis.
DDx:
- Cholangiocarcinoma.
- Metastatic adenocarcinoma.
- Bile duct hamartoma (von Meyenburg complex).
Images
- Bile duct adenoma (ganfyd.org).
- Bile duct adenoma - oncocytic - low mag. (nih.gov).[1]
- Bile duct adenoma - oncocytic - high mag. (nih.gov).[1]
IHC
- CK7 +ve.
- HepPar-1 -ve.
- Ki-67 low.
Others:[3]
- p53 -ve.
- mCEA -ve.
See also
References
- ↑ 1.0 1.1 1.2 Johannesen, EJ.; Wu, Z.; Holly, JS. (2014). "Bile duct adenoma with oncocytic features.". Case Rep Pathol 2014: 282010. doi:10.1155/2014/282010. PMID 24592348.
- ↑ URL: http://www.surgpath4u.com/caseviewer.php?case_no=152. Accessed on: 6 March 2014.
- ↑ 3.0 3.1 Hornick, JL.; Lauwers, GY.; Odze, RD. (Mar 2005). "Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver.". Am J Surg Pathol 29 (3): 381-9. PMID 15725808.