Eosinophilic gastritis

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Eosinophilic gastritis, abbreviated EG, is an uncommon inflammatory process of stomach characterized by abundant eosinophils.

General

  • Rare.

Gross

DDx:

Microscopic

Features:

  • Abundant eosinophils -- >=127 eosinophils/mm2.[1]
    • 30 eosinophils/HPF, if the field diameter of 1 HPF is 0.55 mm.

Notes:

  • Normal range:[1]
    • <38 eosinophils/mm2.
      • Typically ~16 eosinophils/mm2.
  • Mild eosinophilia is seen in:[1]

DDx:

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Focal eosinophilia

STOMACH, BIOPSY:
- BODY AND ANTRAL-TYPE GASTRIC MUCOSA WITH MODERATE CHRONIC ACTIVE INFLAMMATION AND
  FOCAL EOSINOPHILIA.
- NEGATIVE FOR HELICOBACTOR-LIKE ORGANISMS.
- NEGATIVE FOR INTESTINAL METAPLASIA.
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.

COMMENT:
One of four tissue fragments has eosinophilia, with 45 eosinophils/1 HPF (where 1 HPF 
is 0.2376 mm*mm).

See also

References

  1. 1.0 1.1 1.2 Lwin, T.; Melton, SD.; Genta, RM. (Apr 2011). "Eosinophilic gastritis: histopathological characterization and quantification of the normal gastric eosinophil content.". Mod Pathol 24 (4): 556-63. doi:10.1038/modpathol.2010.221. PMID 21169993.