Pleomorphic tumours

Pleomorphic tumours have nuclear pleomorphism.

General differential diagnosis

Adapted from Miller with modifications:^[1]

Tumour	Group	Notes
Melanoma	melanoma
PEComas	mesenchymal lesion
Anaplastic large cell lymphoma	lymphoid
Primary effusion lymphoma	lymphoid
Lymphocyte-depleted Hodgkin lymphoma	lymphoid
Xanthogranuloma	reactive process
Pheochromocytoma	mesenchymal lesion
Choriocarcinoma	carcinoma
Pleomorphic fibroma	mesenchymal lesion
Radiation effect	reactive process
Rhabdomyosarcoma	sarcoma
Leiomyosarcoma	sarcoma
Liposarcoma	sarcoma
Pleomorphic undifferentiated sarcoma	sarcoma
Atypical fibroxanthoma	mesenchymal lesion
Malignant peripheral nerve sheath tumour	sarcoma
Angiosarcoma	sarcoma
Osteosarcoma	sarcoma
Gastrointestinal stromal tumour	sarcoma
Alveolar soft part sarcoma	sarcoma
Malignant solitary fibrous tumour	sarcoma
Inflammatory liposarcoma	sarcoma
Pleomorphic neurothekeoma	mesenchymal lesion
Anaplastic myeloma	lymphoid
Sclerosing extramedullary hematopoetic tumour	lymphoid	rare
Smooth muscle tumour of uncertain malignant potential (STUMP)	mesenchymal lesion	rare, may be seen in the prostate gland^[2]
Inflammatory myxohyaline tumour with Reed-Sternberg like cells	sarcoma	very rare
Pleomorphic hyalinizing angiectatic tumour	sarcoma	very rare

↑ Miller RT. (Sep 2013). Atlantic Diagnostic Immunohistochemistry Symposium. St. John's, NL, Canada.
↑ Nagar, M.; Epstein, JI. (Jun 2011). "Epithelial proliferations in prostatic stromal tumors of uncertain malignant potential (STUMP).". Am J Surg Pathol 35 (6): 898-903. doi:10.1097/PAS.0b013e318214f2f2. PMID 21572264.