Rheumatoid arthritis
Rheumatoid arthritis, commonly abbreviated RA, is an autoimmune disorder.
Skin
General
- May manifest as rheumatoid neutrophilic dermatitis - super rare.[1]
Microscopic
Features:
- Nodular and diffuse pattern.
- Neutrophils.
Joints
Main article: Joints
Microscopic
Features:
- Chronic inflammation (e.g. lymphocytes).
Images:
Rheumatoid nodule
General
- Usually only in seropositive cases.[3]
Microscopic
Features:[3]
- Necrotic collagen bundles with mucin surrounded by:
- Palisading granuloma.
- +/-Eosinophils.
Notes:
- Histomorphologically identical to Granuloma annulare. (???)
DDx:
Images:
- Rheumatoid nodule (granuloma.homestead.com).[4]
- Rheumatoid nodule (granuloma.homestead.com).[4]
- Rheumatoid nodule (utah.edu).[5]
Lung disease
- See Medical lung disease.
RA may involve the lung.
Amyloidosis
- See Amyloidosis.
Amyloidosis may be due to RA.
Felty syndrome
RA may occur in Felty syndrome -- the triad:[6]
- Rheumatoid arthritis.
- Splenomegaly.
- Neutropenia.
Felty syndrome is assoc. with large granular lymphocytic leukemia.[6]
See also
References
- ↑ Mashek, HA.; Pham, CT.; Helm, TN.; Klaus, M. (Jun 1997). "Rheumatoid neutrophilic dermatitis.". Arch Dermatol 133 (6): 757-60. PMID 9197831.
- ↑ URL: http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/msfrm.html. Accessed on: 5 December 2010.
- ↑ 3.0 3.1 Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 299. ISBN 978-0470519035.
- ↑ 4.0 4.1 URL: http://granuloma.homestead.com/palisading.html. Accessed on: 1 November 2010.
- ↑ URL: http://www.pathguy.com/lectures/joints.htm. Accessed on: 1 November 2010.
- ↑ 6.0 6.1 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 328. ISBN 978-1416054542.