S-100
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| S-100 | |
|---|---|
| Immunostain in short | |
.jpg) S-100 staining in a MASC. | |
| Use | malignant melanoma, assess perineural invasion, undifferentiated malignancy |
| Normal staining pattern | nucleus and cytoplasm |
| Positive | benign: nerves, adipose tissue; tumour/other: granular cell tumour, Rosai-Dorfman disease; malignant: malignant melanoma, clear cell sarcoma, malignant peripheral nerve sheath tumour |
S-100, also S100, is a commonly used immunostain. It marks nerves.
Positive
- Nerves.
- Schwannoma.
- Mature adipose tissue.
- Interdigitating dendritic cells.[1]
- Langerhans cell histiocytosis.
- Rosai-Dorfman disease.
- Chordoma - also keratin positive (AE1/AE3, CK19, CAM5.2).[2]
- Granular cell tumour.
- Nodal nevus.
Malignant tumours
- Malignant melanoma - almost 100% sensitive.
- Malignant peripheral nerve sheath tumour.
- Clear cell sarcoma.
- Mammary analogue secretory carcinoma.
See also
References
- ↑ Mesquita, RA.; de Araújo, VC.; Paes, RA.; Nunes, FD.; de Souza, SC.. "Immunohistochemical analysis for CD21, CD35, Caldesmon and S100 protein on dendritic cells types in oral lymphomas.". J Appl Oral Sci 17 (3): 248-53. PMID 19466261.
- ↑ Shen, J.; Shi, Q.; Lu, J.; Wang, DL.; Zou, TM.; Yang, HL.; Zhu, GQ. (Dec 2013). "Histological study of chordoma origin from fetal notochordal cell rests.". Spine (Phila Pa 1976) 38 (25): 2165-70. doi:10.1097/BRS.0000000000000010. PMID 24296480.