Chronic sialadenitis

Chronic sialadenitis is a chronic inflammatory process involving a salivary gland.

Chronic sailolithiasis redirects here. Sialadenitis redirects here. Chronic sclerosing sialadenitis (also known as Küttner tumour) redirects here.

General

• Occasionally associated with malignancy, e.g. adenoid cystic carcinoma.

Etiology:

• Infection.
• Autoimmune (e.g. Sjögren syndrome, systemic lupus erythematosus).
• Other.

Associations:

• Smoking. (???)

Gross

Features:

• Typical location: submandibular salivary gland.
• Salivary gland swelling.

Microscopic

Features:

• Non-neoplastic mononuclear inflammatory infiltrate (lymphocytes, plasma cells).
• Fibrosis.
• +/-Calcifications.

Note:

• If the infiltrate is predominantly lymphocytes Sjögren's is a possibility, and reporting a Focus score should be considered.

DDx:

• Lymphoma - especially MALT lymphoma.
• IgG4-related sialadenitis.

Image

• 

  Chronic sialadenitis. (WC/Nephron)

Sign out

SUBMANDIBULAR GLAND, RIGHT, EXCISION:
- CHRONIC SIALOADENITIS.
- SIALOLITHIASIS.
- TWO BENIGN LYMPH NODES.
- NEGATIVE FOR MALIGNANCY.

Micro

The sections show submandibular salivary gland with a mild patchy mixed mononuclear cell infiltrate, fibrosis and a large benign calcification. No zonal necrosis is identified. Significant nuclear atypia is not identified.

Alternate

The sections show a salivary gland with a patchy mixed mononuclear cell infiltrate and fibrosis. Significant nuclear atypia is not identified. Plasma cells are not prominent. Germinal centres are present.

See also

• Salivary gland.