Proton pump inhibitor effect
Stomach with PPI effect. H&E stain.
Proton pump inhibitor effect, abbreviated PPI effect, is a change seen in the parietal cells of the stomach due to a drug in the proton pump inhibitor class.
Formally, it is stomach with proton pump inhibitor effect.
General
- Due to intake of a proton pump inhibitor (PPI).
- Used to treat gastroesophageal reflux disease.
Some proton pump inhibitors
| Generic name | Brand name(s) |
|---|---|
| Omeprazole | LOSEC |
| Dexlansoprazole | DEXILANT |
| Lansoprazole | PREVACID |
| Esomeprazole | NEXIUM |
| Pantoprazole | PANTOLOC |
| Rabeprazole | PARIET |
Microscopic
- Parietal cell enlargement - key feature.
- Parietal cells typically bulge into the lumen.
- G cell and enterochromaffin cell-like hyperplasia
- Compensatory change due to increased pH in gastric lumen.
- Multiple fundic gland polyps (with PPI use over several months)
- Polyps may regress after PPI is stopped
Images
PPI effect - intermed. mag.
PPI effect - high mag.
PPI effect - very high mag.
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- Usually not reported.
See also
References
- ↑ Driman, DK.; Wright, C.; Tougas, G.; Riddell, RH. (Oct 1996). "Omeprazole produces parietal cell hypertrophy and hyperplasia in humans.". Dig Dis Sci 41 (10): 2039-47. PMID 8888719.
- ↑ topic/stomachPPI.html topic/stomachPPI