Squamous metaplasia of the rectum/anus

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Squamous metaplasia of the anus is a metaplastic change of the columnar epithelium. It can histologically mimic anal intraepithelial neoplasia (AIN), especially. high-grade squamous intraepithelial lesion (HSIL).

Images

  • ISM - very low mag.

  • ISM - low mag.

  • ISM - intermed. mag.

  • ISM - high mag.

IHC

  • p16 -ve
    • Usually weak-to-moderate patchy, not full thickness.
  • Ki-67 - scattered cells positive.

See also

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