Gastric antral vascular ectasia
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Gastric antral vascular ectasia, abbreviated GAVE, is an uncommon pathology of the stomach. It is also known as watermelon stomach due to characteristic endoscopic appearance.[1]
General
- Lesion of the antrum - due to dilated capillaries.
Gross/endoscopic appearance
- Linear red streaks in antrum - oriented toward the pyloric valve... vaguely resembles a watermelon.
Endoscopic images:
Microscopic
Features:[2]
- Fibrin thrombi - characteristic feature.
- Dilated capillaries in lamina propria.
- +/-Foveollar hyperplasia.[3]
DDx:
- Portal hypertensive gastropathy - predominantly in the gastric body, usu. associated with cirrhosis, do not have fibrin thrombi.[4]
Images
GAVE - intermed. mag. (WC)
GAVE - very high mag. (WC)
GAVE - two thrombi - very high mag. (WC)
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STOMACH, BIOPSY: - GASTRIC ANTRAL VASCULAR ECTASIA WITH FOVEOLAR HYPERPLASIA. - MILD CHRONIC ACTIVE ANTRAL GASTRITIS. - NEGATIVE FOR INTESTINAL METAPLASIA. - NEGATIVE FOR DYSPLASIA. - NEGATIVE FOR HELICOBACTER ORGANISMS.
Micro
The sections show antral-type gastric mucosa with dilated lamina propria blood vessels and intravascular fibrin thrombi. There is mild foveolar hyperplasia. Numerous neutrophils are present between the foveollar cells and within the lamina propria. Several large clusters of plasma cells are present in the lamina propria.
See also
References
- ↑ Chatterjee S (July 2008). "Watermelon stomach". CMAJ 179 (2): 162. doi:10.1503/cmaj.080461. PMC 2443230. PMID 18625989. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18625989.
- ↑ Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 118. ISBN 978-0443066573.
- ↑ Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 119. ISBN 978-0443066573.
- ↑ Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 120-1. ISBN 978-0443066573.