Eosinophilic vacuolated tumour
Jump to navigation
Jump to search
High-grade oncocytic renal tumour, abbreviated HOT, is a kidney tumour type currently not recognized by the WHO classification as per the 2016 Blue Book.
General
- Previously lumped into renal hybrid oncocytic/chromophobe tumour.
- Evolving entity.
Microscopic
Features:[1]
- Abundant oncocytic cytoplasm with prominent intracytoplasmic vacuoles.
- Round nuclei
- No "raisinoid" nuclei typical of chromophobe RCC.
- Prominent nucleoli (ISUP nucleolar grade 3).
- No perinuclear halos.
DDx:
- Renal oncocytoma.
- Renal hybrid oncocytic/chromophobe tumour.
- Chromophobe renal cell carcinoma.
- Other renal tumours with eosinophilic cytoplasm.
Images
HOT - low mag. (WC)
HOT - intermed. mag. (WC)
HOT - intermed. mag. (WC)
HOT - high mag. (WC)
HOT - high mag. (WC)
HOT - very high mag. (WC)
IHC
Features:[1]
- PAX8 +ve (13 of 13 cases).
- AE1/AE3 +ve.
- CK18 +ve.
- SDHB +ve.
- CD10 +ve (12 of 13 cases).
- HMB45 -ve.
- Melan A -ve.
- TFE3 -ve.
See also
References
- ↑ 1.0 1.1 He, H.; Trpkov, K.; Martinek, P.; Isikci, OT.; Maggi-Galuzzi, C.; Alaghehbandan, R.; Gill, AJ.; Tretiakova, M. et al. (Dec 2018). ""High-grade oncocytic renal tumor": morphologic, immunohistochemical, and molecular genetic study of 14 cases.". Virchows Arch 473 (6): 725-738. doi:10.1007/s00428-018-2456-4. PMID 30232607.