Giant cell cystitis
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Giant cell cystitis is term used for a benign change of mesenchymal cells in the urinary bladder lamina propria.
Giant cell cystitis is considered a misnomer as may be seen in an otherwise normal bladder that lacks significant inflammation.[1]
General
- Considered a common benign finding; not a clinical entity.[2]
- Reported in up to 1/3 of bladders at autopsy.[3]
Microscopic
Features:[4]
- Scattered atypical mesenchymal cells - mononuclear or multinucleated.
- +/-Nuclear hyperchromasia and/or lobulation.
- Absence of apparent mitotic activity.
DDx:
- Radiation cystitis - history of radiation, more atypical usually with nucleoli.[2]
- Sarcoma of the bladder or metastatic sarcoma - typically more cellular.[2]
- Sarcomatoid change in urothelial carcinoma.
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Urinary Bladder, Biopsy: - Urothelial mucosa with scattered large atypical mesenchymal cells in the lamina propria, prominent smooth muscle and prominent superficial blood vessels. - Urothelium within normal limits. - Thick benign muscularis propria. - NEGATIVE for significant proliferative activity and NEGATIVE for significant inflammation. - NEGATIVE for dysplasia and NEGATIVE for malignancy. Comment: The large mesenchymal cells are a benign change that is referred to as "giant cell cystitis" and may be seen with or without inflammation.
See also
References
- ↑ Hameed, O.; Humphrey, PA. (Mar 2010). "Pseudoneoplastic mimics of prostate and bladder carcinomas.". Arch Pathol Lab Med 134 (3): 427-43. doi:10.1043/1543-2165-134.3.427. PMID 20196670.
- ↑ 2.0 2.1 2.2 Amin, Mahul B. (2010). Diagnostic Pathology: Genitourinary (1st ed.). Amirsys. pp. 2:6. ISBN 978-1931884280.
- ↑ Wells, HG (1938). "Giant cells in cystitis". Arch Pathol 26: 32-43.
- ↑ Amin, Mahul B.; Eble, John; Grignon, David; Srigley, John. (2013). Urological Pathology (1st ed.). Wolters Kluwer. pp. 305. ISBN 978-0781782814.