Pleomorphic lipoma
Pleomorphic lipoma is a rare adipocytic tumour.
General
Gross
- Classically shoulder and neck region in adults.[3]
DDx - shoulder lesions:
Microscopic
Features:
- Multinucleated cells - "floret cells" - key feature.
- Solid eosinophilic cytoplasm.
- Peripheral nuclei - impart a knobby border to the cells.
- Fibrous septa.
Notes:
- May overlap with spindle cell lipoma.[4]
- Floret cell - may look similar to Touton giant cells.
DDx:
- Liposarcoma.[5]
- Ancient neurofibroma.
- Ancient schwannoma.
Images
- Pleomorphic lipoma - low mag. (webpathology.com).
- Pleomorphic lipoma - high mag. (webpathology.com).
IHC
- AR +ve - ~95% in men, ~85% in women.[2]
- CD34 +ve (26 +ve of 26 cases[6]).
- Desmin -ve (0 +ve of 20 cases[6]).
- ER -ve/+ve (5 +ve of 21 cases[6]).
See also
References
- ↑ Persichetti, P.; Di Lella, F.; Marangi, GF.; Cagli, B.; Simone, P.; Tenna, S.; Rabitri, C.; Cassandro, R. et al. "Pleomorphic lipoma: a definite histopathological entity.". Anticancer Res 24 (5B): 3157-9. PMID 15510605.
- ↑ 2.0 2.1 Syed, S.; Martin, AM.; Haupt, H.; Podolski, V.; Brooks, JJ. (Jan 2008). "Frequent detection of androgen receptors in spindle cell lipomas: an explanation for this lesion's male predominance?". Arch Pathol Lab Med 132 (1): 81-3. doi:10.1043/1543-2165(2008)132[81:FDOARI]2.0.CO;2. PMID 18181679.
- ↑ URL: http://www.webpathology.com/image.asp?n=2&Case=435. Accessed on: 3 October 2011.
- ↑ URL: [http://surgpathcriteria.stanford.edu/softfat/spindle_cell_lipoma/ http://surgpathcriteria.stanford.edu/softfat/spindle_cell_lipoma/]. Accessed on: 4 December 2010.
- ↑ Azzopardi, JG.; Iocco, J.; Salm, R. (Jul 1983). "Pleomorphic lipoma: a tumour simulating liposarcoma.". Histopathology 7 (4): 511-23. PMID 6884998.
- ↑ 6.0 6.1 6.2 Cheah, A.; Billings, S.; Goldblum, J.; Hornick, J.; Uddin, N.; Rubin, B. (Feb 2015). "Spindle cell/pleomorphic lipomas of the face: an under-recognized diagnosis.". Histopathology 66 (3): 430-7. doi:10.1111/his.12548. PMID 25219904.