Cytomegalovirus colitis
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| Cytomegalovirus colitis | |
|---|---|
| Diagnosis in short | |
 CMV colitis. H&E stain. (WC) | |
|
| |
| LM | enlarged nucleus - classically in endothelial cells, +/-cytoplasmic inclusions |
| LM DDx | infectious colitis |
| IHC | CMV +ve |
| Site | colon |
|
| |
| Associated Dx | +/-HIV infection |
| Clinical history | +/-immunosuppression, +/-immune incompetent (e.g. transplant recipients) |
| Prevalence | rare |
Cytomegalovirus colitis is a type of colitis caused by cytomegalovirus.
General
- Uncommon.
- Immunosuppressed population at risk, e.g. transplant recipients, individuals with HIV.
- Typically self-limited in immunocompetent patients.[1]
Microscopic
Features:
- Enlarged nucleus - typically in endothelial cells.
- Nucleus classically has peripheral clearing - described as "owl's eye".
- Epithelial cells and lamina propria cells may also be affected.[2]
DDx:
- Infectious colitis without a distinctive morphology.
- CMV colitis superimposed on inflammatory bowel disease.
Images
CMV colitis - intermed. mag. (WC/Nephron)
CMV colitis - high mag. (WC/Nephron)
CMV nuclear inclusions in submucosal vessel - high mag. (WC/MO)
CMV nuclear inclusions in submucosa of colon - high mag. (WC/MO)
www:
- CMV colitis (flickr.com/lunar caustic).
- CMV colitis (flickr.com/lunar caustic)
- CMV colitis (unibas.ch).
IHC
- CMV +ve.
- Increases the sensitivity (compared to H&E alone).[3]
Others:
- HSV-1.
- HSV-2.
- VZV.
- EBV.
Images
See also
References
- ↑ Kim, SH.; Kim, YS.; Kim, HW.; Yoon, HE.; Kim, HK.; Kim, YO.; Yoon, SA. (Apr 2011). "A case of cytomegalovirus colitis in an immunocompetent hemodialysis patient.". Hemodial Int 15 (2): 297-300. doi:10.1111/j.1542-4758.2010.00520.x. PMID 21226839.
- ↑ URL: http://www.annalsgastro.gr/index.php/annalsgastro/article/view/579. Accessed on: 8 February 2016.
- ↑ Beaugerie, L.; Cywiner-Golenzer, C.; Monfort, L.; Girard, PM.; Carbonnel, F.; Ngô, Y.; Cosnes, J.; Rozenbaum, W. et al. (Apr 1997). "Definition and diagnosis of cytomegalovirus colitis in patients infected by human immunodeficiency virus.". J Acquir Immune Defic Syndr Hum Retrovirol 14 (5): 423-9. PMID 9170416.
- ↑ Harano, Y.; Kotajima, L.; Arioka, H. (2015). "Case of cytomegalovirus colitis in an immunocompetent patient: a rare cause of abdominal pain and diarrhea in the elderly.". Int J Gen Med 8: 97-100. doi:10.2147/IJGM.S63771. PMID 25767404.