Tumour suppressor gene

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A tumour suppressor gene is a gene that acts to protect the organism which it is within from developing cancer.

Examples

Gene Syndrome or disease
TP53 (p53)[1] Li-Fraumeni syndrome
BRCA1[2] Familial breast-ovarian cancer 1
RB1[3] Retinoblastoma
VHL[4] Von Hippel-Lindau disease
NF1[5] Neurofibromatosis type 1
TSC1[6] (hamartin) Tuberous sclerosis
TSC2[6] (tuberin) Tuberous sclerosis

See also

References

  1. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 191170
  2. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 113705
  3. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 614041
  4. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608537
  5. ↑ Online 'Mendelian Inheritance in Man' (OMIM) 613113
  6. ↑ 6.0 6.1 Johnson, MW.; Kerfoot, C.; Bushnell, T.; Li, M.; Vinters, HV. (Mar 2001). "Hamartin and tuberin expression in human tissues.". Mod Pathol 14 (3): 202-10. doi:10.1038/modpathol.3880286. PMID 11266527.
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