Testicular atrophy

Testicular atrophy
	Diagnosis in short
	; Atrophic changes of the testis (bottom). H&E stain.
LM	thickening of seminiferous tubule basement membrane, decreased sperm/no sperm present, +/-intertubular fibrosis
Site	testis
Clinical history	undescended testis (cryptorchidism)
Prevalence	not common
Prognosis	benign
Clin. DDx	dependent on history, ?testicular mass
Treatment	none required

Testicular atrophy is relatively common change seen in undescended testes. It is also known as atrophic testis and atrophy of the testis.

Cryptorchidism redirects here.

General

Microscopic appearance identical to cryptorchidism (undescended testis).^[1]

Gross

Decreased size.

Microscopic

Features:^[1]

Thickening of seminiferous tubule basement membrane.
Intertubular fibrosis.
Decreased sperm/no sperm present.

Note:

End-stage testicle - only has Sertoli cell within the seminiferous tubules.

Other considerations (DDx):

Images

Atrophic changes (left) - intermed. mag.
Atrophic changes (left) - high mag.
Atrophic changes (bottom) - high mag.
Testis - very high mag.

www:

Testicular atrophy (surgicalpathologyatlas.com).

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TESTICLE, RIGHT, ORCHIECTOMY:
- ATROPHIC TESTICLE.
- NEGATIVE FOR INTRATUBULAR GERM CELL NEOPLASIA.
- NEGATIVE FOR MALIGNANCY.

Micro

The sections show seminiferous tubules surrounded by thick hyaline sleeves. In a large number of sections only Sertoli cells are found in the tubules.

In some sections poorly defined paucicellular tubular structures reminiscent of seminiferous tubules composed of hyaline material are present; these probably represent obsolete seminiferous tubules. Focally, fibrosis is seen without definite tumour outlines. There is no significant inflammation. The rete testis is identified.

Rare seminiferous tubules have spermatid within. The germ cells seen do not have appreciable nuclear atypia.

Numerous small Leydig cell clusters are seen in some sections.

References

↑ ^1.0 ^1.1 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 506-7. ISBN 978-1416054542.

[Ref_PCPBoD8_506-7-1] 1.0 ^1.1 Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 506-7. ISBN 978-1416054542.

[1]

Testicular atrophy

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