Angiokeratoma

Angiokeratoma
Diagnosis in short
Angiokeratoma. H&E stain.
LM	ectatic superficial dermal vessels with overlying hyperkeratosis (thick stratum corneum); should have "epidermal collarette" (vascular space is surrounded by epidermis on three sides)
LM DDx	venous lake
Site	skin
Syndromes	Fabry disease
Prevalence	uncommon
Prognosis	benign
Clin. DDx	melanocytic lesions, other vascular lesions

Angiokeratoma is a benign skin lesion.

General

• Rare.
• May be seen in the context of Fabry disease.

Notes:

• Shouldn't be confused with angiofibroma which is associated tuberous sclerosis.

Gross

• Dark lesions.

Clinical DDx:

• Melanocytic lesions.

Images

• 

  Angiokeratoma. (WC)

Microscopic

Features:

1. Ectatic superficial dermal vessels.
2. Overlying hyperkeratosis (thick stratum corneum).

• Should have "epidermal collarette".
  • Vascular space surrounded by epidermis on three sides.

Others features:^{[citation needed]}

• Irregular acanthosis.
• Longer rete ridges.

DDx:

• Venous lake.

Images

• 

  Angiokeratoma - low mag. (WC/Nephron)

• 

  Angiokeratoma - intermed. mag. (WC/Nephron)

• 

  Angiokeratoma - high mag. (WC/Nephron)

www:

• Angiokeratoma (pathologyoutlines.com).

Sign out

SKIN LESION, LEFT POPITEAL FOSSA, PUNCH BIOPSY:
- ANGIOKERATOMA.

See also

• Non-malignant skin disease.