Chronic sialadenitis

Chronic sialadenitis is a chronic inflammatory process involving a salivary gland.

Chronic sailolithiasis redirects here. Sialadenitis redirects here.

General

• Occasionally associated with malignancy, e.g. adenoid cystic carcinoma.

Etiology:

• Infection.
• Autoimmune (e.g. Sjögren syndrome, systemic lupus erythematosus).
• Other.

Associations:

• Smoking. (???)

Gross

Features:

• Typical location: submandibular salivary gland.
• Salivary gland swelling.

Microscopic

Features:

• Non-neoplastic mononuclear inflammatory infiltrate (lymphocytes, plasma cells).
• Fibrosis.
• +/-Calcifications.

Note:

• If the infiltrate is predominantly lymphocytes Sjögren's is a possibility, and reporting a Focus score should be considered.

DDx:

• Lymphoma - especially MALT lymphoma.

Image

• 

  Chronic sialadenitis. (WC/Nephron)

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SUBMANDIBULAR GLAND, RIGHT, EXCISION:
- CHRONIC SIALOADENITIS.
- SIALOLITHIASIS.
- TWO BENIGN LYMPH NODES.
- NEGATIVE FOR MALIGNANCY.

Micro

The sections show submandibular salivary gland with a mild patchy mixed mononuclear cell infiltrate, fibrosis and a large benign calcification. No zonal necrosis is identified. Significant nuclear atypia is not identified.

See also

• Salivary gland.