Human immunodeficiency virus, abbreviated HIV, is the causative agent in acquire immune deficiency syndrome (AIDS) - unless you're a nutbar South African president called Thabo Mbeki.^[1]

It is associated with a very wide range of pathology including neoplasias and infections.

HIV-associated pathology

Neoplasia

Kaposi sarcoma.
Hodgkin lymphoma.
Primary effusion lymphoma^[2] - considered to be a special subtype of DLBCL.^[3]
Leiomyomas and leiomyosarcomas in association with EBV.^[4]

Other

Haemophagocytic syndrome.
Castleman disease, plasma cell variant.

Infections

Pneumocystis jiroveci pneumonia (PCP).
Toxoplasmosis.
Cryptosporidiosis.
Tuberculosis.
Mycobacterium avium complex (MAC).
- Consists of: Mycobacterium avium and Mycobacterium intracellulare.
  - MAC = MAI (Mycobacterium avium intracellulare).^[5] (???)

Less common:

Progressive multifocal leukoencephalopathy.
Isosporiasis - caused by Isospora belli.^[6]

AIDS-defining conditions

There is a long list of AIDS-defining illnesses.^[7]

Selected infectious AIDS-defining illnesses

Pneumocystis jiroveci pneumonia.
Candidiasis of esophagus.
Tuberculosis

Selected neoplastic AIDS-defining illnesses

Kaposi sarcoma.
Invasive cervical cancer.
Burkitt lymphoma.

References

↑ URL: http://www.nytimes.com/2008/11/26/world/africa/26aids.html. Accessed on: 19 September 2010.
↑ Staudt MR, Kanan Y, Jeong JH, Papin JF, Hines-Boykin R, Dittmer DP (July 2004). "The tumor microenvironment controls primary effusion lymphoma growth in vivo". Cancer Res. 64 (14): 4790–9. doi:10.1158/0008-5472.CAN-03-3835. PMID 15256448.
↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 322. ISBN 978-1416054542.
↑ McClain, KL.; Joshi, VV.; Murphy, SB. (Oct 1996). "Cancers in children with HIV infection.". Hematol Oncol Clin North Am 10 (5): 1189-201. PMID 8880205.
↑ URL: http://www.pathology.med.umich.edu/greensonlab/JANUNKNOWN.HTML. Accessed on: 25 February 2011.
↑ URL: http://www.pathology.med.umich.edu/greensonlab/DECUNKNOWN.HTML. Accessed on: 25 February 2011.
↑ Schneider E, Whitmore S, Glynn KM, Dominguez K, Mitsch A, McKenna MT (December 2008). "Revised surveillance case definitions for HIV infection among adults, adolescents, and children aged <18 months and for HIV infection and AIDS among children aged 18 months to <13 years--United States, 2008". MMWR Recomm Rep 57 (RR-10): 1–12. PMID 19052530. http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5710a1.htm.

[1] URL: http://www.nytimes.com/2008/11/26/world/africa/26aids.html. Accessed on: 19 September 2010.

[pmid15256448-2] Staudt MR, Kanan Y, Jeong JH, Papin JF, Hines-Boykin R, Dittmer DP (July 2004). "The tumor microenvironment controls primary effusion lymphoma growth in vivo". Cancer Res. 64 (14): 4790–9. doi:10.1158/0008-5472.CAN-03-3835. PMID 15256448.

[3] Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 322. ISBN 978-1416054542.

[pmid8880205-4] McClain, KL.; Joshi, VV.; Murphy, SB. (Oct 1996). "Cancers in children with HIV infection.". Hematol Oncol Clin North Am 10 (5): 1189-201. PMID 8880205.

[5] URL: http://www.pathology.med.umich.edu/greensonlab/JANUNKNOWN.HTML. Accessed on: 25 February 2011.

[6] URL: http://www.pathology.med.umich.edu/greensonlab/DECUNKNOWN.HTML. Accessed on: 25 February 2011.

[pmid19052530-7] Schneider E, Whitmore S, Glynn KM, Dominguez K, Mitsch A, McKenna MT (December 2008). "Revised surveillance case definitions for HIV infection among adults, adolescents, and children aged <18 months and for HIV infection and AIDS among children aged 18 months to <13 years--United States, 2008". MMWR Recomm Rep 57 (RR-10): 1–12. PMID 19052530. http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5710a1.htm.

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Human immunodeficiency virus

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