Low-grade squamous intraepithelial lesion
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Low-grade squamous intraepithelial lesion, abbreviated LSIL, is a pre-cancerous lesions of the uterine cervix.
Increasingly, the term is being applied to other anatomical sites, e.g. vagina.
It is in the larger category of squamous intraepithelial lesion, abbreviated SIL.
General
- Precursor lesion of cervical squamous cell carcinoma.
- Usually associated with human papilloma virus.
SIL is divided into grades:
- Low-grade.
- High-grade.
The new and old terminology
| SIL (current terminology) | LSIL | HSIL |
|---|---|---|
| Recent terminology | CIN I | CIN II, CIN III |
| Very old terminology | mild dysplasia | moderate dysplasia, severe dysplasia |
Treatment
Overview:
- LSIL: follow-up unless persistent. It usually regresses on its own.
Microscopic
Features:[1]
- "Koilocytic atypia":[2]
Note:
- Atypical cells usually close to basement membrane.
- May be seen, focally, in the upper layers.[2]
DDx:
See also
References
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1075-6. ISBN 0-7216-0187-1.
- ↑ 2.0 2.1 Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 146. ISBN 978-0443069208.
- ↑ Roteli-Martins CM, Derchain SF, Martinez EZ, Siqueira SA, Alves VA, Syrjänen KJ (2001). "Morphological diagnosis of HPV lesions and cervical intraepithelial neoplasia (CIN) is highly reproducible". Clin Exp Obstet Gynecol 28 (2): 78–80. PMID 11491378.