Difference between revisions of "Clear cell sugar tumour of the lung"
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*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802170404452 Clear cell sugar tumour of the lung (surgicalpathologyatlas.com)]. | *[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802170404452 Clear cell sugar tumour of the lung (surgicalpathologyatlas.com)]. | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610653/figure/F3/ CCST (nih.gov)].<ref name=pmid19119463/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610653/figure/F3/ CCST (nih.gov)].<ref name=pmid19119463/> | ||
==stains== | |||
*[[PAS]] +ve.<ref name=pmid29276673>{{cite journal |authors=Tsilimigras DI, Bakopoulos A, Ntanasis-Stathopoulos I, Gavriatopoulou M, Moris D, Karaolanis G, Spartalis E, Vagios S, Kalfa M, Salla C, Avgerinos DV |title=Clear cell "sugar tumor" of the lung: Diagnostic features of a rare pulmonary tumor |journal=Respir Med Case Rep |volume=23 |issue= |pages=52–54 |date=2018 |pmid=29276673 |pmc=5734796 |doi=10.1016/j.rmcr.2017.12.001 |url=}}</ref> | |||
==IHC== | ==IHC== | ||
*HMB-45 +ve (nuclear & cytoplasmic). | *HMB-45 +ve (nuclear & cytoplasmic). | ||
==Molecular== | |||
*TFE3 gene fusions - subset of cases.<ref name=pmid20871214>{{cite journal |vauthors=Argani P, Aulmann S, Illei PB, Netto GJ, Ro J, Cho HY, Dogan S, Ladanyi M, Martignoni G, Goldblum JR, Weiss SW |title=A distinctive subset of PEComas harbors TFE3 gene fusions |journal=Am J Surg Pathol |volume=34 |issue=10 |pages=1395–406 |date=October 2010 |pmid=20871214 |doi=10.1097/PAS.0b013e3181f17ac0 |url=}}</ref> | |||
==See also== | ==See also== | ||
Revision as of 15:18, 31 December 2020
Clear cell sugar tumour of the lung is a very rare benign lung tumour.
General
- A PEComa.
- Benign.[1]
- The sugar part in the name clear cell sugar tumour comes from the presence of glycogen; the tumour is PAS positive.[2]
Microscopic
Features:[1]
- Sheets or trabeculae.
- Irregular epithelioid cells with:
- Focally clear cytoplasm.
DDx:
Images
stains
IHC
- HMB-45 +ve (nuclear & cytoplasmic).
Molecular
- TFE3 gene fusions - subset of cases.[3]
See also
References
- ↑ 1.0 1.1 1.2 Kim, WJ.; Kim, SR.; Choe, YH.; Lee, KY.; Park, SJ.; Lee, HB.; Chung, MJ.; Jin, GY. et al. (Dec 2008). "Clear cell "sugar" tumor of the lung: a well-enhanced mass with an early washout pattern on dynamic contrast-enhanced computed tomography.". J Korean Med Sci 23 (6): 1121-4. doi:10.3346/jkms.2008.23.6.1121. PMC 2610653. PMID 19119463. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610653/.
- ↑ 2.0 2.1 Tsilimigras DI, Bakopoulos A, Ntanasis-Stathopoulos I, Gavriatopoulou M, Moris D, Karaolanis G, Spartalis E, Vagios S, Kalfa M, Salla C, Avgerinos DV (2018). "Clear cell "sugar tumor" of the lung: Diagnostic features of a rare pulmonary tumor". Respir Med Case Rep 23: 52–54. doi:10.1016/j.rmcr.2017.12.001. PMC 5734796. PMID 29276673. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734796/.
- ↑ "A distinctive subset of PEComas harbors TFE3 gene fusions". Am J Surg Pathol 34 (10): 1395–406. October 2010. doi:10.1097/PAS.0b013e3181f17ac0. PMID 20871214.