Difference between revisions of "PEComa"
Jump to navigation
Jump to search
(create) |
(→IHC: +micro) |
||
| Line 12: | Line 12: | ||
*Primary extrapulmonary sugar tumour. | *Primary extrapulmonary sugar tumour. | ||
===IHC | ==Microscopic== | ||
Features:<ref name=pmid18080139/> | |||
*Epithelioid morphology. | |||
*Clear or granular cytoplasm. | |||
*Central oval (or round) nucleus. | |||
**Indistinct/small nucleolus. | |||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Renal_angiomyolipoma_%282%29.jpg Renal AML (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Lymphangioleiomyomatosis_-_very_high_mag.jpg LAM - very high mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Lymphangioleiomyomatosis_-_high_mag.jpg LAM - high mag. (WC)]. | |||
==IHC== | |||
*Melanocytic markers | *Melanocytic markers | ||
**HMB-45.<ref name=pmid18080139/> | **HMB-45.<ref name=pmid18080139/> | ||
Revision as of 16:43, 15 April 2011
PEComa is a family of tumours derived from perivascular epithelioid cells (PECs).
General
- Associated with abnormalities in TSC1 and TSC2 - the genes involved in tuberous sclerosis.[1]
The PEComa family
- Angiomyolipoma.
- Lymphangioleiomyomatosis.
- Clear-cell myomelanocytic tumour of ligamentum teres/falciform ligament.
- Abdominopelvic sarcoma of perivascular epitheloid cells.
- Clear-cell sugar tumour (CCST).
- Primary extrapulmonary sugar tumour.
Microscopic
Features:[1]
- Epithelioid morphology.
- Clear or granular cytoplasm.
- Central oval (or round) nucleus.
- Indistinct/small nucleolus.
Images:
IHC
See also
References
- ↑ 1.0 1.1 1.2 1.3 Martignoni G, Pea M, Reghellin D, Zamboni G, Bonetti F (February 2008). "PEComas: the past, the present and the future". Virchows Arch. 452 (2): 119–32. doi:10.1007/s00428-007-0509-1. PMC 2234444. PMID 18080139. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234444/.