Difference between revisions of "TDP-43"
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{{ Infobox immunostain | {{ Infobox immunostain | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = FTLD TSP43 hippocampus.jpg | ||
| Width = | | Width = | ||
| Caption = TDP-43 staining in FTLD-TDP43. (WC) | | Caption = TDP-43 staining in FTLD-TDP43. (WC) | ||
| Line 18: | Line 18: | ||
*Nuclear staining. | *Nuclear staining. | ||
== | ==Inclusion morphology== | ||
* | *fine / coarse skeins. | ||
*dot-like. | |||
*dense-round inclusions. | |||
==Inclusions found== | |||
*[[FTLD TDP-43]] | |||
* Alzheimer disease.<ref>{{Cite journal | last1 = Wilson | first1 = AC. | last2 = Dugger | first2 = BN. | last3 = Dickson | first3 = DW. | last4 = Wang | first4 = DS. | title = TDP-43 in aging and Alzheimer's disease - a review. | journal = Int J Clin Exp Pathol | volume = 4 | issue = 2 | pages = 147-55 | month = Jan | year = 2011 | doi = | PMID = 21326809 }}</ref> | |||
Revision as of 11:52, 5 July 2018
| TDP-43 | |
|---|---|
| Immunostain in short | |
 TDP-43 staining in FTLD-TDP43. (WC) | |
| Normal staining pattern | nuclear staining (physiological) |
| Positive | cytoplasmatic staining (pathological) |
TAR-DNA-binding Protein 43, abbreviated TDP-43 is a neuropathology immunostain used in neurodegenerative diseases.
- Nuclear staining.
Inclusion morphology
- fine / coarse skeins.
- dot-like.
- dense-round inclusions.
Inclusions found
- FTLD TDP-43
- Alzheimer disease.[1]