Difference between revisions of "Porocarcinoma"
Jump to navigation
Jump to search
m (→General) |
|||
| Line 7: | Line 7: | ||
*Very rare ~ most papers are case reports.<ref name=pmid25515648>{{Cite journal | last1 = Riera-Leal | first1 = L. | last2 = Guevara-Gutiérrez | first2 = E. | last3 = Barrientos-García | first3 = JG. | last4 = Madrigal-Kasem | first4 = R. | last5 = Briseño-Rodríguez | first5 = G. | last6 = Tlacuilo-Parra | first6 = A. | title = Eccrine porocarcinoma: epidemiologic and histopathologic characteristics. | journal = Int J Dermatol | volume = 54 | issue = 5 | pages = 580-6 | month = | year = 2015 | doi = 10.1111/ijd.12714 | PMID = 25515648 }}</ref> | *Very rare ~ most papers are case reports.<ref name=pmid25515648>{{Cite journal | last1 = Riera-Leal | first1 = L. | last2 = Guevara-Gutiérrez | first2 = E. | last3 = Barrientos-García | first3 = JG. | last4 = Madrigal-Kasem | first4 = R. | last5 = Briseño-Rodríguez | first5 = G. | last6 = Tlacuilo-Parra | first6 = A. | title = Eccrine porocarcinoma: epidemiologic and histopathologic characteristics. | journal = Int J Dermatol | volume = 54 | issue = 5 | pages = 580-6 | month = | year = 2015 | doi = 10.1111/ijd.12714 | PMID = 25515648 }}</ref> | ||
Clinical - based on meta-analysis of 453 cases: | Clinical features - based on meta-analysis of 453 cases: | ||
*No predominance males versus females. | *No predominance males versus females. | ||
*Aggressive behaviour >30% of cases have metastases at presentation - typically to lymph nodes. | *Aggressive behaviour >30% of cases have metastases at presentation - typically to lymph nodes. | ||
Revision as of 04:40, 6 June 2018
Porocarcinoma is a rare malignant skin tumour that has an aggressive behaviour.[1]
It is also known as eccrine porocarcinoma (abbreviated EPC) and malignant eccrine poroma.[2]
General
Clinical features - based on meta-analysis of 453 cases:
- No predominance males versus females.
- Aggressive behaviour >30% of cases have metastases at presentation - typically to lymph nodes.
Treatment:
- Surgery,
Gross
- Mass or nodule - typically head and neck (40% of cases) or lower extremity (34% of cases).[1]
Microscopic
Features:
- Ductal/eccrine differentiation:[2]
- Intracytoplasmic lumens.
- Multicellular ducts with thin esoinophilic layer.
- Lack granular cells and lack decapitated lumens - features of apocrine differentiation.
- Features of malignancy:[2]
- Desmoplastic stromal response.
- Irregular dermis infiltrating cell clusters.
- +/-Squamous differentiation.
- +/-Basaloid differentiation.
DDx:[3]
- Basal cell carcinoma.
- Squamous cell carcinoma.
- Pyogenic granuloma.
- Verruca vulgaris.
- Adenocarcinoma.
- Malignant melanoma - desmoplastic and nodular variants.
Images
See also
References
- ↑ 1.0 1.1 Salih, AM.; Kakamad, FH.; Baba, HO.; Salih, RQ.; Hawbash, MR.; Mohammed, SH.; Othman, S.; Saeed, YA. et al. (Aug 2017). "Porocarcinoma; presentation and management, a meta-analysis of 453 cases.". Ann Med Surg (Lond) 20: 74-79. doi:10.1016/j.amsu.2017.06.027. PMID 28721214.
- ↑ 2.0 2.1 2.2 Luz, Mde A.; Ogata, DC.; Montenegro, MF.; Biasi, LJ.; Ribeiro, LC. (Jul 2010). "Eccrine porocarcinoma (malignant eccrine poroma): a series of eight challenging cases.". Clinics (Sao Paulo) 65 (7): 739-42. doi:10.1590/S1807-59322010000700014. PMID 20668633.
- ↑ 3.0 3.1 3.2 Abarzúa, Á.; Álvarez-Véliz, S.; Moll-Manzur, C.. "Concomitant poroma and porocarcinoma.". An Bras Dermatol 92 (4): 550-552. doi:10.1590/abd1806-4841.20175719. PMID 28954110.
- ↑ Riera-Leal, L.; Guevara-Gutiérrez, E.; Barrientos-García, JG.; Madrigal-Kasem, R.; Briseño-Rodríguez, G.; Tlacuilo-Parra, A. (2015). "Eccrine porocarcinoma: epidemiologic and histopathologic characteristics.". Int J Dermatol 54 (5): 580-6. doi:10.1111/ijd.12714. PMID 25515648.