Difference between revisions of "Osmotic demyelination syndrome"
Jump to navigation
Jump to search
(split out) |
|||
| Line 1: | Line 1: | ||
'''Osmotic demyelination syndrome''', abbreviated '''ODS''', is a demyelination associated with osmotic imbalances. | '''Osmotic demyelination syndrome''', abbreviated '''ODS''', is a demyelination associated with osmotic imbalances. | ||
It classically affect the | It classically affect the pons and was previously known as '''central pontine myelinolysis'''.<ref name=pmid24745890>{{Cite journal | last1 = Alleman | first1 = AM. | title = Osmotic demyelination syndrome: central pontine myelinolysis and extrapontine myelinolysis. | journal = Semin Ultrasound CT MR | volume = 35 | issue = 2 | pages = 153-9 | month = Apr | year = 2014 | doi = 10.1053/j.sult.2013.09.009 | PMID = 24745890 }}</ref> The name was changed as it is now recognized that it can occur extrapontine.<ref name=pmid26124552>{{Cite journal | last1 = Zunga | first1 = PM. | last2 = Farooq | first2 = O. | last3 = Dar | first3 = MI. | last4 = Dar | first4 = IH. | last5 = Rashid | first5 = S. | last6 = Rather | first6 = AQ. | last7 = Basu | first7 = JA. | last8 = Ashraf | first8 = M. | last9 = Bhat | first9 = JA. | title = Extra pontine osmotic demyelination syndrome. | journal = Ann Neurosci | volume = 22 | issue = 1 | pages = 51-3 | month = Jan | year = 2015 | doi = 10.5214/ans.0972.7531.220212 | PMID = 26124552 }}</ref> | ||
==General== | ==General== | ||
Revision as of 14:59, 18 August 2017
Osmotic demyelination syndrome, abbreviated ODS, is a demyelination associated with osmotic imbalances.
It classically affect the pons and was previously known as central pontine myelinolysis.[1] The name was changed as it is now recognized that it can occur extrapontine.[2]
General
- Classically in the pons, ergo "pontine" is in the name.
- Classically midline, ergo "central" is in the name.
- May occur elsewhere -- known as extrapontine myelinolysis.
Etiology:
- Rapid correction of hyponatremia.[3]
- Tacrolimus post-liver transplant.[4]
- Associated with alcoholism and malnourishment.
Clinical:[5]
- Decreased level of consciousness - most common.
- Quadriplegia.
- Poor prognosis.
Microscopic
Features:[6]
- Myelin loss.
- No inflammation.
- Relative preservation of neurons.
Images
Luxol fast blue (LFB stain) in a case of central pontine myelinolysis (WC/jensflorian)
Myelinophages in CPM showing intracellular myelin fragments (WC/jensflorian)
www
See also
References
- ↑ Alleman, AM. (Apr 2014). "Osmotic demyelination syndrome: central pontine myelinolysis and extrapontine myelinolysis.". Semin Ultrasound CT MR 35 (2): 153-9. doi:10.1053/j.sult.2013.09.009. PMID 24745890.
- ↑ Zunga, PM.; Farooq, O.; Dar, MI.; Dar, IH.; Rashid, S.; Rather, AQ.; Basu, JA.; Ashraf, M. et al. (Jan 2015). "Extra pontine osmotic demyelination syndrome.". Ann Neurosci 22 (1): 51-3. doi:10.5214/ans.0972.7531.220212. PMID 26124552.
- ↑ Chang, Y.; An, DH.; Xing, Y.; Qi, X. (Nov 2011). "Central pontine and extrapontine myelinolysis associated with acute hepatic dysfunction.". Neurol Sci. doi:10.1007/s10072-011-0838-3. PMID 22080394.
- ↑ Fukazawa, K.; Nishida, S.; Aguina, L.; Pretto, E. (Sep 2011). "Central pontine myelinolysis (CPM) associated with tacrolimus (FK506) after liver transplantation.". Ann Transplant 16 (3): 139-42. PMID 21959523.
- ↑ Lai, CC.; Tan, CK.; Lin, SH.; Chen, HW. (Jun 2011). "Central pontine myelinolysis.". CMAJ 183 (9): E605. doi:10.1503/cmaj.090186. PMC 3114939. PMID 21543311. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114939/.
- ↑ 6.0 6.1 URL: http://neuropathology-web.org/chapter6/chapter6dCPM.html. Accessed on: 20 December 2011.