Difference between revisions of "P40"
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===Positive=== | ===Positive=== | ||
*[[Squamous cell carcinoma of the lung]]. | *[[Squamous cell carcinoma of the lung]]. | ||
*[[Urothelial carcinoma]].<ref name=pmid24711443>{{Cite journal | last1 = Brandler | first1 = TC. | last2 = Aziz | first2 = MS. | last3 = Rosen | first3 = LM. | last4 = Bhuiya | first4 = TA. | last5 = Yaskiv | first5 = O. | title = Usefulness of GATA3 and p40 immunostains in the diagnosis of metastatic urothelial carcinoma in cytology specimens. | journal = Cancer Cytopathol | volume = 122 | issue = 6 | pages = 468-73 | month = Jun | year = 2014 | doi = 10.1002/cncy.21424 | PMID = 24711443 }}</ref> | |||
===Negative=== | ===Negative=== | ||
Revision as of 17:24, 20 December 2016
| P40 | |
|---|---|
| Immunostain in short | |
| Similar stains | p63 |
| Use | lung (adenocarcinoma vs. squamous) |
| Normal staining pattern | nuclear staining |
| Positive | squamous cell carcinoma, urothelial carcinoma |
| Negative | prostate carcinoma, most lung adenocarcinoma, breast carcinoma |
p40 an immunostain that is both sensitive and specific for squamous cell carcinoma.
General
- Considered superior to p63 as it is more specific.[1]
- p63 stains a significant number of adenocarcinoma.
Staining
Positive
Negative
See also
- p63.
References
- ↑ Bishop, JA.; Teruya-Feldstein, J.; Westra, WH.; Pelosi, G.; Travis, WD.; Rekhtman, N. (Mar 2012). "p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma.". Mod Pathol 25 (3): 405-15. doi:10.1038/modpathol.2011.173. PMID 22056955.
- ↑ Brandler, TC.; Aziz, MS.; Rosen, LM.; Bhuiya, TA.; Yaskiv, O. (Jun 2014). "Usefulness of GATA3 and p40 immunostains in the diagnosis of metastatic urothelial carcinoma in cytology specimens.". Cancer Cytopathol 122 (6): 468-73. doi:10.1002/cncy.21424. PMID 24711443.