Difference between revisions of "Lentigo simplex"
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'''Lentigo simplex''' is a common benign [[melanocytic lesion]]. | |||
It is also known as ''simple lentigo''.<ref>URL: [http://www.dermnetnz.org/lesions/lentigo-simplex.html http://www.dermnetnz.org/lesions/lentigo-simplex.html]. Accessed on: 27 March 2013.</ref> | |||
==General== | |||
*Benign. | |||
*Usually <40 years old. | |||
Fits into the larger category of ''lentiginous melanocytic proliferations'' - these include:<ref name=Ref_Derm438>{{Ref Derm|438}}</ref> | |||
*[[Solar lentigo]]. | |||
*Lentigo simplex. | |||
*[[Lentiginous nevus]]. | |||
*Lentiginous [[melanoma in situ]]. | |||
Associated syndromes:<ref name=dermamin_ls>URL: [http://dermaamin.com/site/histopathology-of-the-skin/64-l/1852-lentigo-simplex-.html http://dermaamin.com/site/histopathology-of-the-skin/64-l/1852-lentigo-simplex-.html]. Accessed on: 17 December 2012.</ref> | |||
*[[Peutz-Jeghers syndrome]]. | |||
*[[LEOPARD syndrome]]. | |||
*[[LAMB syndrome]]. | |||
==Gross== | |||
*Small flat pigmented lesion.<ref name=Ref_WMSP498>{{Ref WMSP|498}}</ref> | |||
DDx - clinical: | |||
*[[Melanocytic nevus]].<ref name=pmid19536147>{{Cite journal | last1 = Hafner | first1 = C. | last2 = Stoehr | first2 = R. | last3 = van Oers | first3 = JM. | last4 = Zwarthoff | first4 = EC. | last5 = Hofstaedter | first5 = F. | last6 = Klein | first6 = C. | last7 = Landthaler | first7 = M. | last8 = Hartmann | first8 = A. | last9 = Vogt | first9 = T. | title = The absence of BRAF, FGFR3, and PIK3CA mutations differentiates lentigo simplex from melanocytic nevus and solar lentigo. | journal = J Invest Dermatol | volume = 129 | issue = 11 | pages = 2730-5 | month = Nov | year = 2009 | doi = 10.1038/jid.2009.146 | PMID = 19536147 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=Ref_WMSP498>{{Ref WMSP|498}}</ref> | |||
*Melanocytes in epidermis only. | |||
**Melanocytes basally located (normal location) with hyperpigmentation. | |||
*No melanocytic nests. | |||
*+/-Mild/moderate elongation of the rete ridges.<ref name=pmid19536147/> | |||
DDx:<ref name=humpath_ls/> | |||
*[[Solar lentigo]] - solar elastosis, usu. in sun exposed areas. | |||
*[[Ephelis]] (freckle) - change with UV light exposure. | |||
*Melanotic macule. | |||
*[[Lentiginous nevus]] - has melanocytic nests. | |||
===Images=== | |||
*[http://dermaamin.com/site/histopathology-of-the-skin/64-l/1852-lentigo-simplex-.html Lentigo simplex - several images (dermamin.com)].<ref name=dermamin_ls/> | |||
*[http://www.humpath.com/IMG/jpg/lentigo_simplex_20x.jpg Lentigo simplex (humpath.com)].<ref name=humpath_ls>URL: [http://www.humpath.com/?lentigo-simplex http://www.humpath.com/?lentigo-simplex]. Accessed on: 17 December 2012.</ref> | |||
<gallery> | |||
Image:Skin_Tumors-171.jpg | Simple lentigo. (WC) | |||
</gallery> | |||
==Sign out== | |||
<pre> | |||
SKIN LESION, LEFT ABDOMEN, BIOPSY: | |||
- SIMPLE LENTIGO, COMPLETELY EXCISED IN THE PLANE OF SECTION. | |||
</pre> | |||
<pre> | |||
SKIN LESION, LEFT ABDOMEN, BIOPSY: | |||
- BENIGN SIMPLE LENTIGO. | |||
</pre> | |||
===Micro=== | |||
The sections show skin with increased numbers of small pigmented melanocytes at the dermal-epidermal junction. The rete ridges are mildly elongated. No solar damage is apparent. No dermal melanocytes are identified. No melanocytic nests are identified. No nuclear atypia is apparent. | |||
==See also== | |||
*[[Melanocytic lesions]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
Revision as of 16:37, 26 August 2016
Lentigo simplex is a common benign melanocytic lesion.
It is also known as simple lentigo.[1]
General
- Benign.
- Usually <40 years old.
Fits into the larger category of lentiginous melanocytic proliferations - these include:[2]
- Solar lentigo.
- Lentigo simplex.
- Lentiginous nevus.
- Lentiginous melanoma in situ.
Associated syndromes:[3]
Gross
- Small flat pigmented lesion.[4]
DDx - clinical:
Microscopic
Features:[4]
- Melanocytes in epidermis only.
- Melanocytes basally located (normal location) with hyperpigmentation.
- No melanocytic nests.
- +/-Mild/moderate elongation of the rete ridges.[5]
DDx:[6]
- Solar lentigo - solar elastosis, usu. in sun exposed areas.
- Ephelis (freckle) - change with UV light exposure.
- Melanotic macule.
- Lentiginous nevus - has melanocytic nests.
Images
Simple lentigo. (WC)
Sign out
SKIN LESION, LEFT ABDOMEN, BIOPSY: - SIMPLE LENTIGO, COMPLETELY EXCISED IN THE PLANE OF SECTION.
SKIN LESION, LEFT ABDOMEN, BIOPSY: - BENIGN SIMPLE LENTIGO.
Micro
The sections show skin with increased numbers of small pigmented melanocytes at the dermal-epidermal junction. The rete ridges are mildly elongated. No solar damage is apparent. No dermal melanocytes are identified. No melanocytic nests are identified. No nuclear atypia is apparent.
See also
References
- ↑ URL: http://www.dermnetnz.org/lesions/lentigo-simplex.html. Accessed on: 27 March 2013.
- ↑ Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 438. ISBN 978-0443066542.
- ↑ 3.0 3.1 URL: http://dermaamin.com/site/histopathology-of-the-skin/64-l/1852-lentigo-simplex-.html. Accessed on: 17 December 2012.
- ↑ 4.0 4.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 498. ISBN 978-0781765275.
- ↑ 5.0 5.1 Hafner, C.; Stoehr, R.; van Oers, JM.; Zwarthoff, EC.; Hofstaedter, F.; Klein, C.; Landthaler, M.; Hartmann, A. et al. (Nov 2009). "The absence of BRAF, FGFR3, and PIK3CA mutations differentiates lentigo simplex from melanocytic nevus and solar lentigo.". J Invest Dermatol 129 (11): 2730-5. doi:10.1038/jid.2009.146. PMID 19536147.
- ↑ 6.0 6.1 URL: http://www.humpath.com/?lentigo-simplex. Accessed on: 17 December 2012.