Difference between revisions of "Necrobiotic xanthogranuloma"
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==General== | ==General== | ||
*Usually elderly.<ref name=Ref_Derm629>{{Ref Derm|629}}</ref> | *Usually elderly.<ref name=Ref_Derm629>{{Ref Derm|629}}</ref> | ||
*Associated with monoclonal gammopathy in most cases.<ref name=pmid25566570>{{Cite journal | last1 = Seastrom | first1 = S. | last2 = Bookout | first2 = A. | last3 = Hogan | first3 = DJ. | title = Necrobiotic xanthogranuloma without a monoclonal gammopathy. | journal = Cutis | volume = 94 | issue = 6 | pages = 293-6 | month = Dec | year = 2014 | doi = | PMID = 25566570 }}</ref> | |||
==Gross== | ==Gross== | ||
Revision as of 20:14, 17 June 2016
Necrobiotic xanthogranuloma, abbreviated NXG, is a rare granulomatous skin condition.
General
Gross
Features:
- Periorbital - classic location.[3]
Microscopic
Features:[1]
- "Necrobiotic granuloma":
- Palisading granuloma with a core collagen-like material.
- +/-Cholesterol clefts - common.
- +/-Touton giant cells.
- +/-Atypical foreign body-type giant cells +/- asteroid bodies.
DDx:
- Granuloma annulare.
- Necrobiosis lipoidica - has plasma cells.
- Granuloma-forming infections - positive stains for microorganisms.
Image
See also
References
- ↑ 1.0 1.1 Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 629. ISBN 978-0443066542.
- ↑ Seastrom, S.; Bookout, A.; Hogan, DJ. (Dec 2014). "Necrobiotic xanthogranuloma without a monoclonal gammopathy.". Cutis 94 (6): 293-6. PMID 25566570.
- ↑ Fernández-Herrera, J.; Pedraz, J. (Jun 2007). "Necrobiotic xanthogranuloma.". Semin Cutan Med Surg 26 (2): 108-13. doi:10.1016/j.sder.2007.02.008. PMID 17544963.