Difference between revisions of "Oncocytoma of the salivary gland"

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| Micro      = abundant eosinophilic cytoplasm; architecture: solid, trabecular or duct-like
| Micro      = abundant eosinophilic cytoplasm; architecture: solid, trabecular or duct-like
| Subtypes  =
| Subtypes  =
| LMDDx      = [[acinic cell carcinoma]], metastatic [[renal cell carcinoma]], oncocytic carcinoma
| LMDDx      = [[acinic cell carcinoma]], metastatic [[renal cell carcinoma]], oncocytic carcinoma, [[granular cell tumour]]
| Stains    =
| Stains    =
| IHC        = p63 +ve
| IHC        = p63 +ve
Line 64: Line 64:
*Metastatic [[renal cell carcinoma]] - esp. [[chromophobe renal cell carcinoma]].
*Metastatic [[renal cell carcinoma]] - esp. [[chromophobe renal cell carcinoma]].
*Oncocytic carcinoma.
*Oncocytic carcinoma.
*[[Granular cell tumour]].


===Images===
===Images===
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*p63 +ve<ref name=pmid20614263>{{Cite journal  | last1 = McHugh | first1 = JB. | last2 = Hoschar | first2 = AP. | last3 = Dvorakova | first3 = M. | last4 = Parwani | first4 = AV. | last5 = Barnes | first5 = EL. | last6 = Seethala | first6 = RR. | title = p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. | journal = Head Neck Pathol | volume = 1 | issue = 2 | pages = 123-31 | month = Dec | year = 2007 | doi = 10.1007/s12105-007-0031-4 | PMID = 20614263 | PMC = 2807526}}</ref> focally in nucleus.
*p63 +ve<ref name=pmid20614263>{{Cite journal  | last1 = McHugh | first1 = JB. | last2 = Hoschar | first2 = AP. | last3 = Dvorakova | first3 = M. | last4 = Parwani | first4 = AV. | last5 = Barnes | first5 = EL. | last6 = Seethala | first6 = RR. | title = p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. | journal = Head Neck Pathol | volume = 1 | issue = 2 | pages = 123-31 | month = Dec | year = 2007 | doi = 10.1007/s12105-007-0031-4 | PMID = 20614263 | PMC = 2807526}}</ref> focally in nucleus.
*DOG1 -ve.<ref name=pmid26425134>{{Cite journal  | last1 = Canberk | first1 = S. | last2 = Onenerk | first2 = M. | last3 = Sayman | first3 = E. | last4 = Goret | first4 = CC. | last5 = Erkan | first5 = M. | last6 = Atasoy | first6 = T. | last7 = Kilicoglu | first7 = GZ. | title = Is DOG1 really useful in the diagnosis of salivary gland acinic cell carcinoma? - A DOG1 (clone K9) analysis in fine needle aspiration cell blocks and the review of the literature. | journal = Cytojournal | volume = 12 | issue =  | pages = 18 | month =  | year = 2015 | doi = 10.4103/1742-6413.162774 | PMID = 26425134 }}</ref>
*DOG1 -ve.<ref name=pmid26425134>{{Cite journal  | last1 = Canberk | first1 = S. | last2 = Onenerk | first2 = M. | last3 = Sayman | first3 = E. | last4 = Goret | first4 = CC. | last5 = Erkan | first5 = M. | last6 = Atasoy | first6 = T. | last7 = Kilicoglu | first7 = GZ. | title = Is DOG1 really useful in the diagnosis of salivary gland acinic cell carcinoma? - A DOG1 (clone K9) analysis in fine needle aspiration cell blocks and the review of the literature. | journal = Cytojournal | volume = 12 | issue =  | pages = 18 | month =  | year = 2015 | doi = 10.4103/1742-6413.162774 | PMID = 26425134 }}</ref>
==EM==
*Increased numbers of mitochondria.


==See also==
==See also==

Revision as of 15:55, 8 April 2016

Oncocytoma of the salivary gland
Diagnosis in short

Salivary gland oncocytoma. H&E stain. (WC/Nephron)
Synonyms salivary gland oncocytoma
LM abundant eosinophilic cytoplasm; architecture: solid, trabecular or duct-like
LM DDx acinic cell carcinoma, metastatic renal cell carcinoma, oncocytic carcinoma, granular cell tumour
IHC p63 +ve
EM increased numbers of mitochondria
Site salivary gland
Prevalence very rare
Prognosis benign
Clin. DDx other salivary gland tumours

Oncocytoma of the salivary gland (also salivary gland oncocytoma) is a rare benign tumour of the salivary glands.

General

  • No risk of malignant transformation.
  • Rare ~20 reported in literature.[1]
  • Thought to be ~1% of all salivary gland tumours.
  • Typical age: 60s-80s.
  • Associated with radiation exposure.
  • Major salivary glands - usually parotid gland.[2]

Gross

  • Golden brown appearance.

Image

  • Salivary gland oncocytoma (WC/euthman)

Microscopic

Features:

  • Like oncocytomas elsewhere.
    • Abundant eosinophilic cytoplasm (on H&E stain).
      • Due to increased number of mitochrondria.
    • Fine capillaries.
  • Architecture: solid sheets, trabeculae or duct-like structure.[2]

Notes:

  • May have clear cell change.
  • Multiple small incidental lesions = oncocytosis - not oncocytoma.

DDx:

Images

www:

  • Parotid gland oncocytoma - intermed. mag. (WC/Nephron)

  • Parotid gland oncocytoma - high mag. (WC/Nephron)

  • Parotid gland oncocytoma - very high mag. (WC/Nephron)

IHC

  • p63 +ve[3] focally in nucleus.
  • DOG1 -ve.[4]

EM

  • Increased numbers of mitochondria.

See also

References

  1. ↑ Uzunkulaoğlu H, Yazici H, Can IH, Doğan S, Uzunkulaoğlu T (May 2012). "Bilateral oncocytoma in the parotid gland". J Craniofac Surg 23 (3): e246–7. doi:10.1097/SCS.0b013e31824dfccd. PMID 22627459.
  2. ↑ 2.0 2.1 Zhou, CX.; Gao, Y. (Dec 2009). "Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study.". Oral Oncol 45 (12): e232-8. doi:10.1016/j.oraloncology.2009.08.004. PMID 19796983.
  3. ↑ 3.0 3.1 McHugh, JB.; Hoschar, AP.; Dvorakova, M.; Parwani, AV.; Barnes, EL.; Seethala, RR. (Dec 2007). "p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma.". Head Neck Pathol 1 (2): 123-31. doi:10.1007/s12105-007-0031-4. PMC 2807526. PMID 20614263. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807526/.
  4. ↑ Canberk, S.; Onenerk, M.; Sayman, E.; Goret, CC.; Erkan, M.; Atasoy, T.; Kilicoglu, GZ. (2015). "Is DOG1 really useful in the diagnosis of salivary gland acinic cell carcinoma? - A DOG1 (clone K9) analysis in fine needle aspiration cell blocks and the review of the literature.". Cytojournal 12: 18. doi:10.4103/1742-6413.162774. PMID 26425134.
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